Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

Epigenetic mechanisms, which involve DNA and histone modifications, result in the
heritable silencing of genes without a change in their coding sequence. The study of human …

Tet methylcytosine dioxygenase 2 (TET2) is one of the earliest and most frequently mutated
genes in clonal hematopoiesis of indeterminate potential (CHIP) and myeloid cancers …

Gene-modified autologous hematopoietic stem cells (HSC) can provide ample clinical
benefits to subjects suffering from X-linked chronic granulomatous disease (X-CGD), a rare …

Multiple drug resistance (multidrug resistance; MDR), a phenomenon whereby human
tumours that acquire resistance to one type of therapy are found to be resistant to several …

The cyclin-dependent kinase inhibitor p21WAF1/CIP1 is a major player in cell cycle control
and it is mainly regulated at the transcriptional level. Whereas induction of p21 …

Aberrant DNA methylation patterns, including global hypomethylation, gene-specific
hypermethylation/hypomethylation, and loss of imprinting (LOI), are common in acute …

DNA methylation regulates gene expression in normal and malignant cells. The possibility to
reactivate epigenetically silenced genes has generated considerable interest in the …

▪ Abstract Acetylation is a key posttranslational modification of many proteins responsible for
regulating critical intracellular pathways. Although histones are the most thoroughly studied …

Azacytidine-and 5-aza-deoxycytidine (5-aza-CdR)-mediated reactivation of tumor
suppressor genes silenced by promoter methylation has provided an alternate approach in …