Many recent advances have emerged in the telomere and telomerase fields. This Timeline
article highlights the key advances that have expanded our views on the mechanistic …

The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes,
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …

The DNA of telomeres—the terminal DNA-protein complexes of chromosomes—differs
notably from other DNA sequences in both structure and function. Recent work has …

Histone acetylation regulates many cellular processes, and specific acetylation marks, either
singly or in combination, produce distinct outcomes. For example, the acetylation pattern on …

The ends of eukaryotic chromosomes have the potential to be mistaken for damaged or
broken DNA and must therefore be protected from cellular DNA damage response …

We have identified the yeast and human homologs of the SKP1 gene as a suppressor of
cdc4 mutants and as a cyclin F–binding protein. Skp1p indirectly binds cyclin A/Cdk2 …

A multiprotein complex that specifically recognizes cellular origins of DNA replication has
been identified and purified from the yeast Saccharomyces cerevisiae. We observe a strong …

The purpose of this article is to review essential features of the life cycle of the budding yeast
Saccharomyces cerevisiae as a starting point for learning about S. cerevisiae and its cell …

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …