Stimuli-responsive In situ gelling system for nose-to-brain drug delivery

M Agrawal, S Saraf, S Saraf, SK Dubey, A Puri… - Journal of Controlled …, 2020 - Elsevier
The diagnosis and treatment of neurological ailments always remain an utmost challenge for
research fraternity due to the presence of BBB. The intranasal route appeared as an …

[HTML][HTML] Sustained and targeted delivery of hydrophilic drug compounds: A review of existing and novel technologies from bench to bedside

D Hawthorne, A Pannala, S Sandeman… - Journal of Drug Delivery …, 2022 - Elsevier
The sustained and/or targeted delivery of hydrophilic drugs is an important field within drug
delivery, presenting unique challenges when compared to that of hydrophobic drugs. Yet …

Nose to brain delivery of selegiline loaded PLGA/lipid nanoparticles: Synthesis, characterisation and brain pharmacokinetics evaluation

S Raman, AA Khan, S Mahmood - Journal of Drug Delivery Science and …, 2022 - Elsevier
Parkinson's disease (PD) is the second most common progressive neurodegenerative
disease that promotes neuronal cell death. The primary treatment strategy for Parkinson's …

[HTML][HTML] Formulation and evaluation of eudragit RL-100 nanoparticles loaded in-situ forming gel for intranasal delivery of rivastigmine

S Salatin, J Barar, M Barzegar-Jalali… - Advanced …, 2020 - ncbi.nlm.nih.gov
Purpose: Rivastigmine hydrogen tartrate (RHT) is commonly used for the treatment of mild to
moderate Alzheimer's disease (AD). The aim of this work was to formulate in-situ pluronic F …

Thin film hydration versus modified spraying technique to fabricate intranasal spanlastic nanovesicles for rasagiline mesylate brain delivery: Characterization …

MM Ali, RA Shoukri, C Yousry - Drug Delivery and Translational Research, 2023 - Springer
Rasagiline mesylate (RM) is a monoamine oxidase inhibitor that is commonly used to
alleviate the symptoms of Parkinson's disease. However, it suffers from low oral …

Importance of nanoparticles for the delivery of antiparkinsonian drugs

S Silva, AJ Almeida, N Vale - Pharmaceutics, 2021 - mdpi.com
Parkinson's disease (PD) affects around ten million people worldwide and is considered the
second most prevalent neurodegenerative disease after Alzheimer's disease. In addition …

Optimizing phenol-modified hyaluronic acid for designing shape-maintaining biofabricated hydrogel scaffolds in soft tissue engineering

J Simińska-Stanny, F Hachemi, G Dodi… - International journal of …, 2023 - Elsevier
In this study, we developed a well-printable biomaterial ink for 3D printing of shape-
maintaining hydrogel scaffolds. The hydrogel base comprised tyramine-modified hyaluronic …

PLA–PCL–PEG–PCL–PLA based micelles for improving the ocular permeability of dexamethasone: development, characterization, and in vitro evaluation

M Alami-Milani, P Zakeri-Milani… - Pharmaceutical …, 2020 - Taylor & Francis
The aim of the present research was to investigate the feasibility of developing polylactide–
polycaprolactone–polyethylene glycol–polycaprolactone–polylactide (PLA–PCL–PEG–PCL …

Riluzole-loaded nanoparticles to alleviate the symptoms of neurological disorders by attenuating oxidative stress

B Nabi, S Rehman, M Fazil, S Khan… - Drug development and …, 2020 - Taylor & Francis
Purpose: The objective of the research undertaken was to develop the Riluzole (RIZ)
nanoparticles drug delivery system using Transferrin (Tf) as a ligand in the brain. Method …

[HTML][HTML] The prescription design and key properties of nasal gel for CNS drug delivery: A review

M Wang, X Ma, S Zong, Y Su, R Su, H Zhang… - European Journal of …, 2023 - Elsevier
Central nervous system (CNS) diseases are one of the major health problems. However,
blood-brain barrier (BBB) makes traditional oral and intravenous delivery of CNS drugs …