Many cancer therapies produce toxic side effects whose molecular mechanisms await full
elucidation. The most feared and studied side effect of chemotherapeutic drugs is …

Significance: Fatigue is one of the most common symptoms of cancer and its treatment,
manifested in the clinic through weakness and exercise intolerance. These side effects not …

We report on a functional human model to evaluate multi-organ toxicity in a 4-organ system
under continuous flow conditions in a serum-free defined medium utilizing a pumpless …

Exercise has been suggested to ameliorate the detrimental effects of chemotherapy on
skeletal muscle. The aim of this study was to compare the effects of different exercise …

Background: Cytokines such as tumor necrosis factor-α (TNFα) have been implicated in
cardiac dysfunction and toxicity associated with doxorubicin (DOX). Although TNFα can elicit …

Aim Loss of skeletal muscle mass is a common clinical finding in cancer patients. The
purpose of this meta‐analysis and systematic review was to quantify the effect of doxorubicin …

How breast cancer and its treatments affect skeletal muscle is not well defined. To address
this question, we assessed skeletal muscle structure and protein expression in 13 women …

The tumor microenvironment is a complex and dynamic ecosystem composed of various
physical cues and biochemical signals that facilitate cancer progression, and tumor …

Key points Although doxorubicin is a highly effective anti‐tumour agent, the administration of
this drug is associated with significant side effects, including contractile dysfunction and …

Doxorubicin, a commonly prescribed chemotherapeutic agent, causes skeletal muscle
wasting in cancer patients undergoing treatment and increases mitochondrial reactive …