Over the last ten years there has been a huge increase in development and applications of
organocatalysis in which the catalyst acts as a nucleophile. Amidines and guanidines are …

This review article presents how nitrogen‐centred Lewis bases were modified in order to
increase their reactivity in catalytic processes. As examples, we focus on alcohol acylation …

Electron deficient, bivalent sulfur atoms have two areas of positive electrostatic potential, a
consequence of the low-lying σ* orbitals of the C–S bond that are available for interaction …

Abstract The importance of 1, 5‐O⋅⋅⋅ chalcogen (Ch) interactions in isochalcogenourea
catalysis (Ch= O, S, Se) is investigated. Conformational analyses of N‐acyl …

Compared with the well-developed C–C and C–N axial chirality, the asymmetric synthesis of
N–N axial chirality remains elusive and challenging. Herein we report the first …

Isothiourea-catalyzed annulations between 2-acyl benzazoles and α, β-unsaturated acyl
ammonium intermediates are selectively tuned to form either lactam or lactone heterocycles …

Highly enantioselective [4+ 2] cyclizations of azadienes with in situ generated ketenes were
developed through sequential visible-light photoactivation/isothiourea catalysis, which offers …

Homobenzotetramisole (HBTM), a ring-expanded analogue of the previously reported
catalyst BTM, displays higher catalytic activity and a different structure-selectivity profile. It …

Benzotetramisole promotes the catalytic asymmetric [2, 3]-rearrangement of allylic
quaternary ammonium salts (either isolated or prepared in situ from p-nitrophenyl …

This review covers recent developments relating to organocatalyzed transformations by
chiral isothioureas (ITUs) since their original introduction by Birman in 2006. This class of …