Abstract P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …

Currently, the numbers of patients with cancer, fibrosis, diabetes, chronic kidney disease,
stroke and osteoporosis are increasing fast and fast. It's critical necessary to discovery lead …

A transient inflammatory signal can initiate an epigenetic switch from nontransformed to
cancer cells via a positive feedback loop involving NF-κB, Lin28, let-7, and IL-6. We identify …

Multidrug resistance (MDR) of cancer tissue is a phenomenon in which cancer cells exhibit
reduced sensitivity to a large group of unrelated drugs with different mechanisms of …

Resistance to chemotherapy is a major cause of treatment failure in human cancer.
Accumulating evidence has indicated that the acquisition of resistance to chemotherapeutic …

Although the first-line rituximab plus cyclophosphamide, doxorubicin, vincristine, and
prednisone regimen (R-CHOP) substantially improved outcomes for patients with diffuse …

Background This study aims to evaluate the efficacy and therapeutic mechanism of bufalin
on lung adenocarcinoma (LUAD) through a comprehensive strategy integrating network …

LAPTM4B (lysosomal protein transmembrane 4 beta) is a newly identified cancer-
associated gene. Both of its mRNA and the encoded LAPTM4B-35 protein are significantly …

Objective Multidrug resistance (MDR) is the major barrier to the successful treatment of
chemotherapy. Compounds from nature products working as MDR sensitizers provided new …

The phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signal transduction
pathway is commonly misregulated in lymphoma and associated with tumorigenesis and …