Cutaneous leishmaniasis is a major public health problem and causes a range of diseases
from self-healing infections to chronic disfiguring disease. Currently, there is no vaccine for …

Cutaneous leishmaniases have persisted for centuries as chronically disfiguring parasitic
infections affecting millions of people across the subtropics. Symptoms range from the more …

Cutaneous and mucosal leishmaniasis, caused in South America by Leishmania
braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [SbV]) …

Viruses are the most abundant biological entities on Earth and play a significant role in the
evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of …

Tegumentary Leishmaniasis (TL) is endemic in Latin America, and Brazil contributes
approximately 20 thousand cases per year. The pathogenesis of TL, however, is still not fully …

The presence of the endogenous Leishmania RNA virus 1 (LRV1) replicating stably within
some parasite species has been associated with the development of more severe forms of …

Knowledge of viral diversity is expanding greatly, but many lineages remain underexplored.
We surveyed RNA viruses in 52 cultured monoxenous relatives of the human parasite …

Background Infection with Leishmania parasites causes mainly cutaneous lesions at the site
of the sand fly bite. Inflammatory metastatic forms have been reported with Leishmania …

Background Atypical cutaneous leishmaniasis (ACL) has become progressively more
frequent in Corte de Pedra, Northeast Brazil. Herein we characterize clinical presentation …

Cutaneous leishmaniasis has various outcomes, ranging from self-healing reddened
papules to extensive open ulcerations that metastasise to secondary sites and are often …