Glycogen and its metabolism: some new developments and old themes

PJ Roach, AA Depaoli-Roach, TD Hurley… - Biochemical …, 2012 - portlandpress.com
Glycogen is a branched polymer of glucose that acts as a store of energy in times of
nutritional sufficiency for utilization in times of need. Its metabolism has been the subject of …

AMPK in health and disease

GR Steinberg, BE Kemp - Physiological reviews, 2009 - journals.physiology.org
The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

AMP‐activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives

B Viollet, B Guigas, J Leclerc, S Hébrard… - Acta …, 2009 - Wiley Online Library
As the liver is central in the maintenance of glucose homeostasis and energy storage,
knowledge of the physiology as well as physiopathology of hepatic energy metabolism is a …

The glycogen-binding domain on the AMPK β subunit allows the kinase to act as a glycogen sensor

A McBride, S Ghilagaber, A Nikolaev, DG Hardie - Cell metabolism, 2009 - cell.com
AMPK β subunits contain a conserved domain that causes association with glycogen.
Although glycogen availability is known to affect AMPK regulation in vivo, the molecular …

Analysis of hepatic glycogen‐associated proteins

D Stapleton, C Nelson, K Parsawar, D McClain… - …, 2010 - Wiley Online Library
Glycogen particles are associated with a population of proteins that mediate its biological
functions, including: management of glucose flux into and out of the glycogen particle …

Comparative structural analyses of purified glycogen particles from rat liver, human skeletal muscle and commercial preparations

JH Ryu, J Drain, JH Kim, S McGee… - International journal of …, 2009 - Elsevier
Glycogen is a cellular energy store that is crucial for whole body energy metabolism,
metabolic regulation and exercise performance. To understand glycogen structure we have …

Brain glycogen structure and its associated proteins: past, present and future

MK Brewer, MS Gentry - Brain glycogen metabolism, 2019 - Springer
Brain Glycogen Structure and Its Associated Proteins: Past, Present and Future | SpringerLink
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Structure and function of AMP‐activated protein kinase

JS Oakhill, JW Scott, BE Kemp - Acta physiologica, 2009 - Wiley Online Library
AMP‐activated protein kinase (AMPK) regulates metabolism in response to energy demand
and supply. AMPK is activated in response to rises in intracellular AMP or calcium‐mediated …

Skeletal muscle AMPK is not activated during 2 h of moderate intensity exercise at∼ 65% in endurance trained men

GK McConell, GD Wadley, K Le Plastrier… - The Journal of …, 2020 - Wiley Online Library
Key points AMP‐activated protein kinase (AMPK) is considered a major regulator of skeletal
muscle metabolism during exercise. However, we previously showed that, although AMPK …

Changes in glycogen structure over feeding cycle sheds new light on blood-glucose control

MA Sullivan, STN Aroney, S Li, FJ Warren… - …, 2014 - ACS Publications
Liver glycogen, a highly branched polymer of glucose, is important for maintaining blood-
glucose homeostasis. It was recently shown that db/db mice, a model for Type 2 diabetes …