Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms
ranging from gene amplification to post-transcriptional modification. Their localization within …

Podosomes and invadopodia are unique actin-rich adhesions that establish close contact to
the substratum but can also degrade components of the extracellular matrix. Accordingly …

Podosomes and invadopodia, collectively known as invadosomes, are cell-matrix contacts
in a variety of cell types, such as monocytic cells or cancer cells, that have to cross tissue …

Tissue infiltration of macrophages, although critical for innate immunity, is also involved in
pathologies, such as chronic inflammation and cancer. In vivo, macrophages migrate mostly …

The bone resorption function of osteoclasts is dependent on the integrity of the actin
cytoskeleton. Depending on the substratum upon which the osteoclasts are spread, there …

Members of the solute carrier (SLC) 36 family are involved in transmembrane movement of
amino acids and derivatives. SLC36 consists of four members. SLC36A1 and SLC36A2 both …

Src-family tyrosine kinases (SFKs), which participate in a variety of signal transduction
events, are known to localize to the cytoplasmic face of the plasma membrane through lipid …

The hematopoietic cell kinase (HCK) is a member of the SRC family of cytoplasmic tyrosine
kinases (SFKs), and is expressed in cells of the myeloid and B-lymphocyte cell lineages …

Invadosomes are adhesive mechanosensory modules composed of a dense F-actin core
surrounded by a ring of adhesion molecules and able to infiltrate compact tissue …

Podosomes are adhesion and invasion structures that are particularly prominent in cells of
the monocytic lineage such as macrophages, dendritic cells, and osteoclasts. They are …