Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Calcium is used in many cellular processes and is maintained within the cell as free calcium
at low concentrations (approximately 100 nM), compared with extracellular (millimolar) …

New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

The identification of MPTP, a relatively simple compound which causes selective
degeneration of the substantia nigra after systemic administration, has had an a significant …

Parkinson's disease (PD) is a chronic and progressive disorder characterized
neuropathologically by loss of dopamine neurons in the substantia nigra, intracellular …

Inflammatory activation of microglia is a hallmark of several disorders of the central nervous
system. In addition to protecting the brain against inflammatory insults, microglia are …

The NLRP3 inflammasome signaling pathway is a major contributor to the
neuroinflammatory process in the central nervous system. Oxidative stress and …

Mitochondrial abnormalities have been identified as a central mechanism in multiple
neurodegenerative diseases and, therefore, the mitochondria have been explored as a …

Parkinson's disease (PD) affects millions around the world. The Braak hypothesis proposes
that in PD a pathologic agent may penetrate the nervous system via the olfactory bulb, gut …