Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission

KF Baker, D McDonald, G Hulme, R Hussain… - Nature …, 2024 - nature.com
Immune-mediated inflammatory diseases (IMIDs) are typically characterised by relapsing
and remitting flares of inflammation. However, the unpredictability of disease flares impedes …

Regulatory T lymphocytes as a treatment method for rheumatoid arthritis–superiority of allogeneic to autologous cells

J Chmiel, M Stasiak, M Skrzypkowska, L Samson… - Heliyon, 2024 - cell.com
Cellular therapies utilizing regulatory T cells (Tregs) have flourished in the autoimmunity
space as a new pillar of medicine. These cells have shown a great promise in the treatment …

Exhausted Lag-3+ CD4+ T cells are increased in pediatric Inflammatory Bowel Disease

A Schnell, C Aicher, PA Schnegelsberg… - Clinical and …, 2024 - academic.oup.com
T cells are one of the main drivers of inflammatory bowel diseases (IBD). Infliximab (IFX) is
used in the treatment of IBD as an anti-inflammatory drug to induce remission by neutralizing …

High-throughput Treg cell receptor sequencing reveals differential immune repertoires in rheumatoid arthritis with kidney deficiency

L Zhang, W Jiao, H Deng, C Hu, J Xu, J Yu, L Liu… - PeerJ, 2023 - peerj.com
Background Regulatory T (Treg) cells are important immune cells that are regulated by
adaptive immunity in the composition of Treg-cell subsets and T-cell receptors (TCRs). Treg …

Treg Cells in Ischemic Stroke: A Small Key to a Great Orchestrion

OA Zhukova, DA Chudakova… - Journal of Clinical …, 2023 - journals.eco-vector.com
Ischemic stroke is a global medical problem and one of the leading causes of death or
disability worldwide. The main approach of ischemic stroke therapy in the most acute period …