Salmonella enterica represents a major human and animal pathogen. Many S. enterica
genomes have been completed and many more genome sequencing projects are …

Salmonella Typhimurium has a broad arsenal of genes that are tightly regulated and
coordinated to facilitate adaptation to the various host environments it colonizes. The …

Itaconate (methylenesuccinate) was recently identified as a mammalian metabolite whose
production is substantially induced during macrophage activation. This compound is a …

Itaconic acid is an important biomass‐derived chemical building block but has also recently
been identified as a metabolite produced in mammals, which has antimicrobial activity. The …

Pools of mutants of minimal complexity but maximal coverage of genes of interest facilitate
screening for genes under selection in a particular environment. We constructed individual …

Natural resistance-associated macrophage proteins (Nramp) are multispecific symporters
facilitating proton-dependent import of divalent metals. Nramp1 restricts microbial access to …

Abstract Background Infections with Salmonella cause significant morbidity and mortality
worldwide. Replication of Salmonella typhimurium inside its host cell is a model system for …

Abstract Background Metabolic reconstructions (MRs) are common denominators in systems
biology and represent biochemical, genetic, and genomic (BiGG) knowledge-bases for …

To cause a systemic infection, Salmonella must respond to many environmental cues during
mouse infection and express specific subsets of genes in a temporal and spatial manner, but …

Itaconic acid is an important platform chemical that can easily be incorporated into polymers
and has the potential to replace petrochemical-based acrylic or methacrylic acid. A number …