Nanoparticles loaded with pharmacologically active plant-derived natural products: Biomedical applications and toxicity

S Peng, Y Wang, Z Sun, L Zhao, Y Huang, X Fu… - Colloids and Surfaces B …, 2023 - Elsevier
Pharmacologically active natural products have played a significant role in the history of
drug development. They have acted as sources of therapeutic drugs for various diseases …

Protective effects of Vitis vinifera (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities: A comprehensive review

J Tabeshpour, S Mehri… - Phytotherapy …, 2018 - Wiley Online Library
Vitis vinifera (grape) is one of the “most‐produced fruit” in the world. Grape seeds are a
valuable source of phenolic compounds including resveratrol (RSV). Grape and one of its …

Traditional oriental medicine for sensorineural hearing loss: Can ethnopharmacology contribute to potential drug discovery?

R Castaneda, S Natarajan, SY Jeong, BN Hong… - Journal of …, 2019 - Elsevier
Abstract Ethnopharmacological relevance In Traditional Oriental Medicine (TOM), the
development of hearing pathologies is related to an inadequate nourishment of the ears by …

Age-related hearing loss and its potential drug candidates: a systematic review

S Hu, Q Sun, F Xu, N Jiang, J Gao - Chinese Medicine, 2023 - Springer
Background Age-related hearing loss (ARHL) is one of the main illnesses afflicting the aged
population and has a significant negative impact on society, economy, and health. However …

Prevention and restoration of hearing loss associated with the use of cisplatin

F Chirtes, S Albu - BioMed Research International, 2014 - Wiley Online Library
Background. Cisplatin is a well known platinum‐based chemotherapeutic agent used for the
treatment of various malignant tumours. A frequent side effect of cisplatin therapy is …

Effects of natural products on cisplatin ototoxicity and chemotherapeutic efficacy

LP Rybak, I Alberts, S Patel… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Cisplatin is a very effective chemotherapeutic agent against a variety of solid
tumors. Unfortunately, cisplatin causes permanent sensorineural hearing loss in at least two …

Protective effect of gallic acid against cisplatin-induced ototoxicity in rats

K Kilic, MS Sakat, FNE Akdemir, S Yildirim… - Brazilian journal of …, 2019 - SciELO Brasil
Introduction: Cisplatin is an antineoplastic agent widely used in the treatment of a variety of
cancers. Ototoxicity is one of the main side-effects restricting the use of cisplatin. Objective …

[HTML][HTML] The effect of antioxidant supplementation in patients with tinnitus and normal hearing or hearing loss: a randomized, double-blind, placebo controlled trial

AI Petridou, ET Zagora, P Petridis, GS Korres… - Nutrients, 2019 - mdpi.com
Tinnitus is the perception of sound in the absence of any external stimulus. Oxidative stress
is possibly involved in its pathogenesis and a variety of antioxidant compounds have been …

Allicin protects auditory hair cells and spiral ganglion neurons from cisplatin-Induced apoptosis

X Wu, X Li, Y Song, H Li, X Bai, W Liu, Y Han, L Xu… - …, 2017 - Elsevier
Cisplatin is a broad-spectrum anticancer drug that is commonly used in the clinic. Ototoxicity
is one of the major side effects of this drug, which caused irreversible sensorineural hearing …

Efficiency of resveratrol in the prevention and treatment of age‑related hearing loss

T Muderris, AS Yar Sağlam… - Experimental and …, 2022 - spandidos-publications.com
Age‑related hearing loss (ARHL) is a major public health concern, which is characterized by
gradual, progressive sensorineural hearing loss and deterioration of sound localization, with …