Tear film mucins: front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins

RR Hodges, DA Dartt - Experimental eye research, 2013 - Elsevier
The ocular surface including the cornea and conjunctiva and its overlying tear film are the
first tissues of the eye to interact with the external environment. The tear film is complex …

[HTML][HTML] Concise review: comparison of culture membranes used for tissue engineered conjunctival epithelial equivalents

JR Eidet, DA Dartt, TP Utheim - Journal of functional biomaterials, 2015 - mdpi.com
The conjunctival epithelium plays an important role in ensuring the optical clarity of the
cornea by providing lubrication to maintain a smooth, refractive surface, by producing …

[HTML][HTML] Human conjunctival stem cells are predominantly located in the medial canthal and inferior forniceal areas

RMK Stewart, CM Sheridan, PS Hiscott… - … & visual science, 2015 - arvojournals.org
Purpose.: The conjunctiva plays a key role in ocular surface defence and maintenance of the
tear film. Ex vivo expansion of conjunctival epithelial cells offers potential to reconstruct the …

[HTML][HTML] Clinical outcomes of xeno-free expansion and transplantation of autologous ocular surface epithelial stem cells via contact lens delivery: a prospective case …

S Bobba, S Chow, S Watson, N Di Girolamo - Stem Cell research & …, 2015 - Springer
Introduction Depletion of limbal stem cells leads to a debilitating condition known as limbal
stem cell deficiency, characterised by impaired corneal wound healing and poor vision. The …

[HTML][HTML] Electrospun collagen/poly (L-lactic acid‑co‑ε‑caprolactone) scaffolds for conjunctival tissue engineering

Q Yao, W Zhang, Y Hu, J Chen… - Experimental and …, 2017 - spandidos-publications.com
Conjunctival injuries are general but intractable ocular surface diseases, the sequelae of
which are particularly challenging to treat. A promising therapy for conjunctival injuries is to …

[HTML][HTML] A novel application of electrospun silk fibroin/poly (l-lactic acid-co-ε-caprolactone) scaffolds for conjunctiva reconstruction

Q Yao, Y Hu, F Yu, W Zhang, Y Fu - RSC advances, 2018 - pubs.rsc.org
Electrospun hybrid nanofibers prepared using combinations of natural and synthetic
polymers have been widely investigated in tissue engineering. In this study, silk fibroin (SF) …

Development of decellularized conjunctiva as a substrate for the ex vivo expansion of conjunctival epithelium

S Kasbekar, SB Kaye, RL Williams… - Journal of Tissue …, 2018 - Wiley Online Library
This study was performed to develop a method to decellularize human conjunctiva and to
characterize the tissue in terms of its deoxyribose nucleic acid (DNA) content, tensile …

[HTML][HTML] Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells

OA Utheim, L Pasovic, S Ræder, JR Eidet, IG Fostad… - PLoS …, 2019 - journals.plos.org
Purpose Transplantation of limbal stem cells is a promising therapy for limbal stem cell
deficiency. Limbal cells can be harvested from either a healthy part of the patient's eye or the …

Ex-vivo ocular surface stem cell therapies: current techniques, applications, hurdles and future directions

RI Angunawela, JS Mehta, JT Daniels - Expert Reviews in Molecular …, 2013 - cambridge.org
Engineered tissue derived from ocular surface stem cells (SCs) are a cutting edge
biotechnology for repair and restoration of severely damaged eyes as a result of ocular …

[HTML][HTML] Tissue Harvesting Site and Culture Medium Affect Attachment, Growth, and Phenotype of Ex Vivo Expanded Oral Mucosal Epithelial Cells

R Islam, JR Eidet, RA Badian, M Lippestad… - Scientific Reports, 2017 - nature.com
Transplantation of cultured oral mucosal epithelial cells (OMECs) is a promising treatment
strategy for limbal stem cell deficiency. In order to improve the culture method, we …