Throughout the nervous system, moment-to-moment communication relies on postsynaptic
receptors to detect neurotransmitters and change the membrane potential. For the Cys-loop …

It is over forty years since the major neurotransmitters and their protein receptors were
identified, and over twenty years since determination of the first amino-acid sequences of the …

Pentameric ligand-gated ion channels (pLGICs) are key players in the early events of
electrical signal transduction at chemical synapses. The family codes for a structurally …

The X-ray structure of a pentameric ligand-gated ion channel from Erwinia chrysanthemi
(ELIC) has recently provided structural insight into this family of ion channels at high …

Orthologs of the pentameric receptor channels that mediate fast synaptic transmission in the
central and peripheral nervous systems have been found in several bacterial species and in …

This review outlines recent insights into ligand recognition, channel gating and ion
permeation for the family of pentameric ligand-gated ion channels (pLGICs). These …

The nicotinic acetylcholine receptor (nAChR) is the prototypic member of the'Cys-
loop'superfamily of ligand-gated ion channels which mediate synaptic neurotransmission …

The nicotinic acetylcholine (ACh) receptor, at the neuromuscular junction, is a
neurotransmitter-gated ion channel that has been fine-tuned through evolution to transduce …

Since the discovery of the major excitatory and inhibitory neurotransmitters and their
receptors in the brain, many have deliberated over their likely structures and how these may …

The concept of allosteric interaction was initially proposed to account for the inhibitory
feedback mechanism mediated by bacterial regulatory enzymes. In contrast with the …