Imaging advances in chronic obstructive pulmonary disease. Insights from the genetic epidemiology of chronic obstructive pulmonary disease (COPDGene) study

SP Bhatt, GR Washko, EA Hoffman… - American journal of …, 2019 - atsjournals.org
The Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study,
which began in 2007, is an ongoing multicenter observational cohort study of more than …

Clinical epidemiology of COPD: insights from 10 years of the COPDGene study

DJ Maselli, SP Bhatt, A Anzueto, RP Bowler… - Chest, 2019 - Elsevier
The Genetic Epidemiology of COPD (COPDGene) study is a noninterventional, multicenter,
longitudinal analysis of> 10,000 subjects, including smokers with a≥ 10 pack-year history …

Airway-occluding mucus plugs and mortality in patients with chronic obstructive pulmonary disease

AA Diaz, JL Orejas, S Grumley, HP Nath, W Wang… - Jama, 2023 - jamanetwork.com
Importance Airway mucus plugs are common in patients with chronic obstructive pulmonary
disease (COPD); however, the association of airway mucus plugging and mortality in …

[HTML][HTML] COPDGene® 2019: redefining the diagnosis of chronic obstructive pulmonary disease

KE Lowe, EA Regan, A Anzueto, E Austin… - … Diseases: Journal of …, 2019 - ncbi.nlm.nih.gov
Background: Chronic obstructive pulmonary disease (COPD) remains a major cause of
morbidity and mortality. Present-day diagnostic criteria are largely based solely on …

Acute exacerbations and lung function loss in smokers with and without chronic obstructive pulmonary disease

MT Dransfield, KM Kunisaki, MJ Strand… - American journal of …, 2017 - atsjournals.org
Rationale: Acute exacerbations of chronic obstructive pulmonary disease (COPD) increase
the risk of death and drive healthcare costs, but whether they accelerate loss of lung function …

Pulmonary arterial enlargement and acute exacerbations of COPD

JM Wells, GR Washko, MLK Han… - New England journal …, 2012 - Mass Medical Soc
Background Exacerbations of chronic obstructive pulmonary disease (COPD) are
associated with accelerated loss of lung function and death. Identification of patients at risk …

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease

JH Yun, A Lamb, R Chase, D Singh, MM Parker… - Journal of allergy and …, 2018 - Elsevier
Background Eosinophilic airway inflammation in patients with chronic obstructive pulmonary
disease (COPD) is associated with exacerbations and responsivity to steroids, suggesting …

Longitudinal phenotypes and mortality in preserved ratio impaired spirometry in the COPDGene study

ES Wan, S Fortis, EA Regan, J Hokanson… - American journal of …, 2018 - atsjournals.org
Rationale: Increasing awareness of the prevalence and significance of Preserved Ratio
Impaired Spirometry (PRISm), alternatively known as restrictive or Global Initiative for …

Deep learning assessment of progression of emphysema and fibrotic interstitial lung abnormality

SY Ash, B Choi, A Oh, DA Lynch… - American Journal of …, 2023 - atsjournals.org
Rationale: Although studies have evaluated emphysema and fibrotic interstitial lung
abnormality individually, less is known about their combined progression. Objectives: To …

Causes of and clinical features associated with death in tobacco cigarette users by lung function impairment

WW Labaki, T Gu, S Murray, JL Curtis… - American Journal of …, 2023 - atsjournals.org
Rationale: Cigarette smoking contributes to the risk of death through different mechanisms.
Objectives: To determine how causes of and clinical features associated with death vary in …