Integrins belong to a large family of αβ heterodimeric transmembrane proteins first
recognized as adhesion molecules that bind to dedicated elements of the extracellular …

Extracellular matrix, via its receptors the integrins, has emerged as a crucial factor in cancer
development. The α2β1 integrin is a major collagen receptor that is widely expressed and …

Activation of latent transforming growth factor (TGF)-β2 is incompletely understood. Unlike
TGF-β1 and β3, the TGF-β2 prodomain lacks a seven-residue RGDLXX (L/I) integrin …

Leukemia is a cancer of the white blood cells, with over 54,000 new cases per year
diagnosed worldwide and a 5-year survival rate below 60%. This highlights a need for …

Chemotherapeutic drug resistance in acute lymphoblastic leukemia (ALL) is a significant
problem, resulting in poor responsiveness to first-line treatment or relapse after transient …

Background Gastric cancer is one of the deadliest cancers, currently available therapies
have limited success. Cancer-associated fibroblasts (CAFs) are pivotal cells in the stroma of …

The interaction between leukemia cells and the bone microenvironment is known to provide
drug resistance in leukemia cells. This phenomenon, called cell adhesion-mediated drug …

The integrin “very late antigen-4”(VLA-4) is expressed by numerous cells of hematopoietic
origin and possesses a key function in the cellular immune response, eg, by mediating …

Integrin-mediated attachment to extracellular matrix (ECM) is crucial for cancer progression.
Malignant T cells such as acute lymphoblastic leukemia (T-ALL) express β1 integrins, which …

Therapy-induced presentation of cell surface calreticulin (CRT) is a pro-phagocytic
immunogen beneficial for invoking anti-tumor immunity. Here, we characterized the roles of …