What are quantitative traits and how can they be used in autism research?

K Lyall - Autism Research, 2023 - Wiley Online Library
Quantitative traits are measurable characteristics distributed along a continuous scale
thought to relate to underlying biology. There is growing interest in the use of quantitative …

'I'm not just being difficult... I'm finding it difficult': A qualitative approach to understanding experiences of autistic parents when interacting with statutory services …

S Radev, M Freeth, AR Thompson - Autism, 2024 - journals.sagepub.com
The experiences of autistic parents when interacting with statutory services for their autistic
children is not well understood. This study investigates the experiences of autistic parents' …

Allelic contribution of Nrxn1α to autism-relevant behavioral phenotypes in mice

B Xu, Y Ho, M Fasolino, J Medina, WT O'Brien… - PLoS …, 2023 - journals.plos.org
Copy number variations (CNVs) in the Neurexin 1 (NRXN1) gene, which encodes a
presynaptic protein involved in neurotransmitter release, are some of the most frequently …

[HTML][HTML] The mirror neuron system compensates for amygdala dysfunction-associated social deficits in individuals with higher autistic traits

L Xu, X Zheng, S Yao, J Li, M Fu, K Li, W Zhao, H Li… - NeuroImage, 2022 - Elsevier
The amygdala is a core node in the social brain which exhibits structural and functional
abnormalities in Autism spectrum disorder and there is evidence that the mirror neuron …

Age effects on autism heritability and etiological stability of autistic traits

MI Martini, A Butwicka, E Du Rietz… - Journal of Child …, 2024 - Wiley Online Library
Background Autism and autistic traits onset in childhood but persist into adulthood. Little is
known about how genetic and environmental factors influence autism and autistic traits into …

Calibration, not maladaptation: Beyond “fast life history trajectories” in the prediction of adult psychological dysfunction.

JL Martínez, C Hasty, D Morabito… - Evolutionary …, 2024 - psycnet.apa.org
Consistent with adaptive calibration models, the current study provides evidence that levels
of unpredictability in childhood (assessed via disruptive changes in maternal employment …

[HTML][HTML] A study of the genetic architecture of social responsiveness in families with parental schizophrenia or bipolar disorder and population-based controls

L Veddum, AN Greve, M Gregersen, AK Andreassen… - Psychiatry …, 2023 - Elsevier
Twin-studies of social responsiveness have reported moderate to high heritabilities, but
studies using parent–child data are lacking. Additionally, social impairments have been …

Sleep and Activity Patterns in Autism Spectrum Disorder

JD Weissenkampen, A Ghorai, M Fasolino… - bioRxiv, 2024 - biorxiv.org
Background: Autism spectrum disorder (ASD) is a highly heritable and heterogeneous
neurodevelopmental disorder characterized by impaired social interactions, repetitive …

Systematic Review and Meta-Analysis: Research Using the Autism Polygenic Score

MM de Wit, MJ Morgan, I Libedinsky, C Austerberry… - medRxiv, 2024 - medrxiv.org
Objective: Genetic factors play a substantial role in the etiology of autism and its co-
occurrence with other conditions and traits. The autism polygenic score, derived from the …

The Utility of Biomarkers for Assessment and Intervention in Neurodevelopmental Disorders

S Guldner, J Ernst, F Nees, N Holz - Digital Technologies for Learning and …, 2024 - Springer
The inherent heterogeneity of neurodevelopmental disorders (NDDs) such as attention
deficit hyperactivity disorders (ADHD) and autism spectrum disorder (ASD) underscores a …