Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable
from milk thistle (Silybum marianum) seeds, has anti-oxidant, anti-inflammatory, anti-cancer …

Modern medicine relies on a small number of key biologics, which can be found in nature
but require further characterization and purification before they can be used. Since the …

Berberine hydrochloride is a plant alkaloid with versatile medicinal applications, yet it has
suffered from multiple limitations in its usage. Nonetheless, the acknowledged role of …

Abstract Design of Experiments (DoE) techniques were used to identify and optimize the
parameters involved in the formulation of triclabendazole pH-sensitive Eudragit® …

Biopolymers have gained tremendous attention in many daily life applications, including
medical applications, in the past few years. Obstetrics and gynecology are two fields dealing …

The aim of this work was to develop, optimize and characterize a silymarin-laden
polyvinylpyrrolidone (PVP)-polyethylene glycol (PEG) polymeric composite to resolve low …

Poor solubility is the major challenge involved in the formulation development of new
chemical entities (NCEs), as more than 40% of NCEs are practically insoluble in water. Solid …

Abstract Approximately 70–80% of drugs in clinical drug development suffer low aqueous
solubility, poor oral bioavailability, and limited intestinal permeability. Flavonoids are a …

In this study, syringic acid–loaded TPGS liposome (SA-TPGS-Ls) was successfully prepared
to improve oral bioavailability of syringic acid (SA). SA is a natural and notable antioxidant …

Silymarin (SIL) is a poorly water-soluble flavonoid reported for different pharmacological
properties. Its therapeutic applications are limited due to poor water solubility. In this study …