Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

WDJ Tremlett, DM Goodman, TR Steel, S Kumar… - Coordination chemistry …, 2021 - Elsevier
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

Ruthenium complexes in the fight against pathogenic microorganisms. An extensive review

AC Munteanu, V Uivarosi - Pharmaceutics, 2021 - mdpi.com
The widespread use of antibiotics has resulted in the emergence of drug-resistant
populations of microorganisms. Clearly, one can see the need to develop new, more …

New organometallic ruthenium (II) compounds synergistically show cytotoxic, antimetastatic and antiangiogenic activities for the treatment of metastatic cancer

Y Wang, J Jin, L Shu, T Li, S Lu… - … A European Journal, 2020 - Wiley Online Library
In this study, we newly designed and synthesized a small library of ten structurally related C,
N‐cyclometalated ruthenium (II) complexes containing various pyridine‐functionalized NHC …

[HTML][HTML] Design, synthesis, characterization of zirconium (IV), cadmium (II) and iron (III) complexes derived from Schiff base 2-aminomethylbenzimidazole, 2 …

AN Al-Hakimi, F Alminderej, L Aroua, SK Alhag… - Arabian Journal of …, 2020 - Elsevier
Abstract (E)-1-((((1H-benzo [d] imidazol-2-yl) methyl) imino) methyl) naphthalen-2-ol, ligand
was synthesized by condensation of (1H-benzo [d] imidazol-2-yl) methanamine, with 2 …

Transition Metal Complexes as Antimalarial Agents: A Review

A Mandal, R Kushwaha, AA Mandal, S Bajpai… - …, 2023 - Wiley Online Library
In antimalarial drug development research, overcoming drug resistance has been a major
challenge for researchers. Nowadays, several drugs like chloroquine, mefloquine …

Recent advances in the biological investigation of organometallic platinum-group metal (Ir, Ru, Rh, Os, Pd, Pt) complexes as antimalarial agents

M Mbaba, TM Golding, GS Smith - Molecules, 2020 - mdpi.com
In the face of the recent pandemic and emergence of infectious diseases of viral origin,
research on parasitic diseases such as malaria continues to remain critical and innovative …

Synthesis and biological evaluation of mixed-ligand cyclometalated iridium (III)–quinoline complexes

Y Yang, CM Wang, FH Pan, QP Qin, QJ Xie… - Dalton …, 2021 - pubs.rsc.org
With the aim of gaining new insight into the underlying apoptosis mechanisms and in vivo
efficacy of cyclometalated Ir (III) complexes as metalodrugs, six new cyclometalated Ir (III) …

[HTML][HTML] The quest of the best–A SAR study of trithiolato-bridged dinuclear Ruthenium (II)-Arene compounds presenting antiparasitic properties

E Păunescu, G Boubaker, O Desiatkina… - European journal of …, 2021 - Elsevier
A structure activity relationship (SAR) study of a library of 56 compounds (54 ruthenium and
2 osmium derivatives) based on the trithiolato-bridged dinuclear ruthenium (II)-arene …

Development of mitochondria targeting aie‐active cyclometalated iridium complexes as potent antimalarial agents

G Kumari, A Gupta, RK Sah, A Gautam… - Advanced …, 2023 - Wiley Online Library
The emergence of resistance to conventional antimalarial treatments remains a major cause
for concern. New drugs that target the distinct development stages of Plasmodium parasites …

Exploring Ruthenium‐Based Organometallic Inhibitors against Plasmodium falciparum Calcium Dependent Kinase 2 (PfCDPK2): A Combined Ensemble Docking, QM …

D Patel, M Athar, PC Jha - ChemistrySelect, 2021 - Wiley Online Library
Recent advances in the metal‐organic framework (MOF) have accelerated the discovery of
novel metal‐based anticancer, antibacterial and antimalarial compounds. This is …