From the earliest comparisons of RNA production with steady-state levels, it has been clear
that cells transcribe more RNA than they accumulate, implying the existence of active RNA …

Although the nuclear pore complex (NPC) is best known for its primary function as the key
regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of …

The rates of mRNA synthesis and degradation determine cellular mRNA levels and can be
monitored by comparative dynamic transcriptome analysis (cDTA) that uses nonperturbing …

Eukaryotic PIN (PilT N-terminal) domain proteins are ribonucleases involved in quality
control, metabolism and maturation of mRNA and rRNA. The majority of prokaryotic PIN …

Messenger RNAs undergo 5'capping, splicing, 3'-end processing, and export before
translation in the cytoplasm. It has become clear that these mRNA processing events are …

Background The major role of enzymatic toxins that target nucleic acids in biological
conflicts at all levels has become increasingly apparent thanks in large part to the advances …

Nuclear and cytoplasmic forms of the yeast exosome share 10 components, of which only
Rrp44/Dis3 is believed to possess 3′ exonuclease activity. We report that expression only …

Prokaryotes have evolved a multitude of defense systems to protect against phage
predation. Some of these resemble eukaryotic genes involved in antiviral responses. Here …

Exchange of macromolecules between the nucleus and cytoplasm is a key regulatory event
in the expression of a cell's genome. This exchange requires a dedicated transport …

Proper regulation of ribosome biosynthesis is mandatory for cellular adaptation, growth and
proliferation. Ribosome biogenesis is the most energetically demanding cellular process …