Hypothalamic syndrome

HL Müller, M Tauber, EA Lawson, J Özyurt… - Nature reviews Disease …, 2022 - nature.com
Hypothalamic syndrome (HS) is a rare disorder caused by disease-related and/or treatment-
related injury to the hypothalamus, most commonly associated with rare, non-cancerous …

Endocrine disorders in Prader-Willi syndrome: a model to understand and treat hypothalamic dysfunction

M Tauber, C Hoybye - The Lancet Diabetes & Endocrinology, 2021 - thelancet.com
Prader-Willi syndrome is a rare genetic neurodevelopmental disorder resulting from the loss
of expression of maternally imprinted genes located in the paternal chromosomal region …

Current and emerging therapies for managing hyperphagia and obesity in Prader‐Willi syndrome: A narrative review

Q Tan, CE Orsso, EC Deehan, L Triador… - Obesity …, 2020 - Wiley Online Library
In early childhood, individuals with Prader‐Willi syndrome (PWS) experience excess weight
gain and severe hyperphagia with food compulsivity, which often leads to early onset morbid …

Mental health challenges during COVID-19: perspectives from parents with children with neurodevelopmental disabilities

G Currie, B Finlay, A Seth, C Roth… - … Journal of Qualitative …, 2022 - Taylor & Francis
Background The global pandemic and subsequent denials, delays, and disruptions in
essential daily activities created significant challenges for children with neurodevelopmental …

Resilience in familial caregivers of children with developmental disabilities: A meta-analysis

CI Iacob, E Avram, D Cojocaru, IR Podina - Journal of autism and …, 2020 - Springer
The aim of this meta-analysis was to investigate factors associated with resilience in familial
caregivers of children with developmental disabilities. The protocol was registered in the …

Intranasal carbetocin reduces hyperphagia, anxiousness, and distress in prader-willi syndrome: CARE-PWS phase 3 trial

E Roof, CL Deal, SE McCandless… - The Journal of …, 2023 - academic.oup.com
Abstract Context Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by
endocrine and neuropsychiatric problems including hyperphagia, anxiousness, and …

Quality of life outcomes in two phase 3 trials of setmelanotide in patients with obesity due to LEPR or POMC deficiency

P Kühnen, M Wabitsch, J von Schnurbein… - Orphanet journal of rare …, 2022 - Springer
Introduction Individuals with proopiomelanocortin (POMC) or leptin receptor (LEPR)
deficiency are young and experience severe obesity, hyperphagia, and comorbidities, which …

A profile of mental health and behaviour in Prader–Willi syndrome

SM Feighan, M Hughes, K Maunder… - Journal of …, 2020 - Wiley Online Library
Abstract Background Prader–Willi syndrome (PWS) is a neurogenetic syndrome with an
associated behavioural phenotype and a high incidence of behaviours of concern and …

Characteristics and relationship between hyperphagia, anxiety, behavioral challenges and caregiver burden in Prader-Willi syndrome

N Kayadjanian, C Vrana-Diaz, J Bohonowych… - PLoS …, 2021 - journals.plos.org
Objectives Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by
maladaptive behaviors, amongst which hyperphagia is a life-long concern for individuals …

Approach to the Patient With Prader–Willi Syndrome

C Höybye, M Tauber - The Journal of Clinical Endocrinology & …, 2022 - academic.oup.com
Prader–Willi syndrome (PWS) is a rare, multisystemic, genetic disorder involving the
hypothalamus. It is caused by loss of expression of paternally inherited genes in …