MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

R Rupaimoole, FJ Slack - Nature reviews Drug discovery, 2017 - nature.com
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

Flow-induced reprogramming of endothelial cells in atherosclerosis

IA Tamargo, KI Baek, Y Kim, C Park, H Jo - Nature Reviews Cardiology, 2023 - nature.com
Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral
artery disease continue to be leading causes of death worldwide despite the success of …

Macrophage-mediated inflammation in normal and diabetic wound healing

AE Boniakowski, AS Kimball, BN Jacobs… - The Journal of …, 2017 - journals.aai.org
The healing of cutaneous wounds is dependent on the progression through distinct, yet
overlapping phases of wound healing, including hemostasis, inflammation, proliferation, and …

Noncoding RNA s in disease

E Lekka, J Hall - FEBS letters, 2018 - Wiley Online Library
Noncoding RNA s are emerging as potent and multifunctional regulators in all biological
processes. In parallel, a rapidly growing number of studies has unravelled associations …

Epigenetics across the human lifespan

RR Kanherkar, N Bhatia-Dey, AB Csoka - Frontiers in cell and …, 2014 - frontiersin.org
Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

Oxidative stress and new pathogenetic mechanisms in endothelial dysfunction: potential diagnostic biomarkers and therapeutic targets

MG Scioli, G Storti, F D'Amico… - Journal of Clinical …, 2020 - mdpi.com
Cardiovascular diseases (CVD), including heart and pathological circulatory conditions, are
the world's leading cause of mortality and morbidity. Endothelial dysfunction involved in …

Dysfunctional wound healing in diabetic foot ulcers: new crossroads

FM Davis, A Kimball, A Boniakowski… - Current diabetes reports, 2018 - Springer
Abstract Purpose of Review Diabetic foot ulcerations (DFU) affect 25% of patients with
diabetes mellitus during their lifetime and constitute a major health problem as they are often …

Semi-supervised learning for potential human microRNA-disease associations inference

X Chen, GY Yan - Scientific reports, 2014 - nature.com
MicroRNAs play critical role in the development and progression of various diseases.
Predicting potential miRNA-disease associations from vast amount of biological data is an …

[HTML][HTML] Anti-apoptosis and cell survival: a review

L Portt, G Norman, C Clapp, M Greenwood… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Type I programmed cell death (PCD) or apoptosis is critical for cellular self-destruction for a
variety of processes such as development or the prevention of oncogenic transformation …

A hybrid CNN-LSTM model for pre-miRNA classification

A Tasdelen, B Sen - Scientific reports, 2021 - nature.com
Abstract miRNAs (or microRNAs) are small, endogenous, and noncoding RNAs construct of
about 22 nucleotides. Cumulative evidence from biological experiments shows that miRNAs …