Emerging brain‐pathophysiology‐mimetic platforms for studying neurodegenerative diseases: brain organoids and brains‐on‐a‐chip

S Bang, S Lee, N Choi, HN Kim - Advanced Healthcare …, 2021 - Wiley Online Library
Neurodegenerative diseases are a group of disorders characterized by progressive
degeneration of the structural and functional integrity of the central and peripheral nervous …

[HTML][HTML] Engineered neural circuits for modeling brain physiology and neuropathology

S Bang, KS Hwang, S Jeong, IJ Cho, N Choi, J Kim… - Acta Biomaterialia, 2021 - Elsevier
The neural circuits of the central nervous system are the regulatory pathways for feeling,
motion control, learning, and memory, and their dysfunction is closely related to various …

Brain organoid-on-a-chip: A next-generation human brain avatar for recapitulating human brain physiology and pathology

J Song, S Bang, N Choi, HN Kim - Biomicrofluidics, 2022 - pubs.aip.org
Neurodegenerative diseases and neurodevelopmental disorders have become increasingly
prevalent; however, the development of new pharmaceuticals to treat these diseases has …

Bifurcations of enhanced neuronal bursting activities induced by the negative current mediated by inhibitory autapse

Y Li, H Gu, X Ding - Nonlinear Dynamics, 2019 - Springer
In contrast to the traditional viewpoint that inhibitory effect can often induce the reduction of
neural firing activities, negative self-feedback current mediated by inhibitory autapse is …

Eye‐Mimicked Neural Network Composed of Photosensitive Neural Spheroids with Human Opsin Proteins

B Park, S Bang, KS Hwang, YK Cha, J Kwak… - Advanced …, 2023 - Wiley Online Library
An in vitro model, composed of the short‐wavelength human opsins and rhodopsins, is
created. Two types of photosensitive neural spheroids are transfected for selective reaction …

Nanoscale Patterning of In Vitro Neuronal Circuits

JC Mateus, S Weaver, D van Swaay, AF Renz… - ACS …, 2022 - ACS Publications
Methods for patterning neurons in vitro have gradually improved and are used to investigate
questions that are difficult to address in or ex vivo. Though these techniques guide axons …

Nonlinear mechanisms for opposite responses of bursting activities induced by inhibitory autapse with fast and slow time scale

Y Yang, Y Li, H Gu, C Qi - Nonlinear Dynamics, 2023 - Springer
Fast and slow inhibitory synapses, respectively, induce anti-and in-phase synchronizations,
showing different roles of synapse with different time scales. In the present paper, the …

Paradoxical enhancement of neuronal bursting response to negative feedback of autapse and the nonlinear mechanism

B Lu, H Gu, X Wang, H Hua - Chaos, Solitons & Fractals, 2021 - Elsevier
Paradoxical phenomena such as synchronization and post inhibitory rebound spike induced
by the inhibitory effects are important for both nonlinear science and neuroscience. In the …

Passive-Flow-Based MPS: Emerging Physiological Flow-Mimetic Platforms for Studying Effects of Flow on Single Tissues and Inter-tissue Interactions

G Jin, D Kim, S Mun, S Bang - BioChip Journal, 2024 - Springer
Flow at various scales, such as perfusion flow and interstitial flow, is a critical component of
the physiology of living systems. Microphysiological system (MPS), which is designed to …

Critical analysis in the advancement of cell-based assays for botulinum neurotoxin

G Ambrin, S Cai, BR Singh - Critical Reviews in Microbiology, 2023 - Taylor & Francis
The study on botulinum neurotoxins (BoNTs) has rapidly evolved for their structure and
functions as opposed to them being poisons or cures. Since their discoveries, the scientific …