Novel therapeutic strategies targeting HIV integrase
PK Quashie, RD Sloan, MA Wainberg - BMC medicine, 2012 - Springer
Integration of the viral genome into host cell chromatin is a pivotal and unique step in the
replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically …
replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically …
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance
The development of HIV integrase (IN) strand transfer inhibitors (INSTIs) and our
understanding of viral resistance to these molecules have been hampered by a paucity of …
understanding of viral resistance to these molecules have been hampered by a paucity of …
Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase
E Choi, JR Mallareddy, D Lu, S Kolluru - Future science OA, 2018 - Taylor & Francis
AIDS caused by the infection of HIV is a prevalent problem today. Rapid development of
drug resistance to existing drug classes has called for the discovery of new targets. Within …
drug resistance to existing drug classes has called for the discovery of new targets. Within …
First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G
M Li, SMD Shandilya, MA Carpenter… - ACS chemical …, 2012 - ACS Publications
APOBEC3G is a single-stranded DNA cytosine deaminase that comprises part of the innate
immune response to viruses and transposons. Although APOBEC3G is the prototype for …
immune response to viruses and transposons. Although APOBEC3G is the prototype for …
Inhibiting the HIV integration process: past, present, and the future
R Di Santo - Journal of medicinal chemistry, 2014 - ACS Publications
HIV integrase (IN) catalyzes the insertion into the genome of the infected human cell of viral
DNA produced by the retrotranscription process. The discovery of raltegravir validated the …
DNA produced by the retrotranscription process. The discovery of raltegravir validated the …
HIV drug resistance and the advent of integrase inhibitors
PK Quashie, T Mesplède, MA Wainberg - Current infectious disease …, 2013 - Springer
This review focuses on the topic of HIV integrase inhibitors that are potent antiretroviral
drugs that efficiently decrease viral load in patients. However, emergence of resistance …
drugs that efficiently decrease viral load in patients. However, emergence of resistance …
The HIV-1 integrase monomer induces a specific interaction with LTR DNA for concerted integration
The assembly mechanism for the human immunodeficiency virus type 1 (HIV) synaptic
complex (SC) capable of concerted integration is unknown. Molecular and structural studies …
complex (SC) capable of concerted integration is unknown. Molecular and structural studies …
[HTML][HTML] Multifunctional facets of retrovirus integrase
The retrovirus integrase (IN) is responsible for integration of the reverse transcribed linear
cDNA into the host DNA genome. First, IN cleaves a dinucleotide from the 3'OH blunt ends of …
cDNA into the host DNA genome. First, IN cleaves a dinucleotide from the 3'OH blunt ends of …
The Need for Development of New HIV‐1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance
MA Wainberg - Scientifica, 2012 - Wiley Online Library
The use of highly active antiretroviral therapy (HAART) involves combinations of drugs to
achieve maximal virological response and reduce the potential for the emergence of …
achieve maximal virological response and reduce the potential for the emergence of …
Critical appraisal of elvitegravir in the treatment of HIV-1/AIDS
KK Pandey - HIV/AIDS-Research and Palliative Care, 2014 - Taylor & Francis
Human immunodeficiency virus type 1 (HIV-1) integrase inhibitors belong to a novel class of
antiretroviral drugs with high potency and better tolerability. Elvitegravir (EVG) is the second …
antiretroviral drugs with high potency and better tolerability. Elvitegravir (EVG) is the second …