BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

BACKGROUND A normal chromosomal constitution defined through PGT-A assessing all
chromosomes on trophectoderm (TE) biopsies represents the strongest predictor of embryo …

BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

This review considers how our understanding of preimplantation embryo metabolism has
progressed since the pioneering work on this topic in the late 1960s and early 1970s …

In this essay, we propose that embryos express a metabolic phenotype necessarily different
from that of differentiated somatic cells and more like that of rapidly proliferating cancer cells …

In the efforts aimed at improving the quality of in-vitro-matured human oocytes, the dynamic
balance and roles of pro-/antioxidants merit further consideration. In-vitromaturation (IVM) is …

This review examines the 'Quiet Embryo Hypothesis' which proposes that viable
preimplantation embryos operate at metabolite or nutrient turnover rates distributed within …

Recurrent pregnancy loss (RPL) is a common and distressing disorder. Chromosomal errors
in the embryo are the single most common cause, whereas uterine factors are invariably …

Background The aetiology of recurrent miscarriage (RM) remains largely unexplained.
Women with RM have a shorter time to pregnancy interval than normally fertile women …

Background Infertility in dairy cattle is a concern where reduced fertilization rates and high
embryonic loss are contributing factors. Studies of the paternal contribution to reproductive …