Background Small-molecules that disrupt the binding between glucokinase and glucokinase
regulatory protein (GKRP) in the liver represent a potential new class of glucose-lowering …

Precision medicine, the concept that specific treatments can be targeted to groups of
individuals with specific genetic, cellular, or molecular features, is a key aspect of modern …

Objective: Previous studies have shown that patients with hereditary fructose intolerance
(HFI) are characterized by a greater intrahepatic triglyceride content, despite a fructose …

Glucokinase (GCK) is a key enzyme in glucose sensing and glycemic regulation. In humans,
mutations in the GCK gene cause maturity-onset diabetes of the young 2 (MODY-2), a …

Abstract Background Natural HbA1c levels in GCK Maturity-onset diabetes of the young
(GCK-MODY) patients often sit above the diagnostic threshold for type 2 diabetes (T2D) …

Aims Glucokinase (GCK) acts as the glucose sensor in maintaining glucose homeostasis.
The inactivating mutation of the GCK gene leads to glucokinase-maturity onset diabetes of …

Kidney disease is one of the most prevalent chronic conditions and is a frequent
complication of diabetes, cardiovascular disease, and obesity. Recent advances in …

Natural HbA1c levels in GCK-MODY patients often sit above the diagnostic threshold for
type 2 diabetes (T2D). Standard treatments to lower HbA1c levels are ineffective in these …

OBJECTIVE Glucokinase (GCK) acts as a component of the “glucose sensor” in pancreatic β-
cells and possibly in other tissues, including the brain. However,> 99% of GCK in the body is …

Increased glycemic exposure, even below the diagnostic criteria for diabetes mellitus, is
crucial in the pathogenesis of diabetic microvascular complications represented by …