The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …

Conspectus In nature, enzymes are a powerful medium for the construction of
enantiomerically pure chemicals, which always inspires synthetic chemists to explore new …

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes | Chemical Reviews ACS
ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications …

The enantioselective synthesis of spirocycles has long been pursued by organic chemists.
Despite their unique 3D properties and presence in several natural products, the difficulty in …

N‐Heterocyclic carbene (NHC) catalysis has emerged as a powerful stratagem in organic
synthesis to construct complex molecules primarily by polarity reversal (umpolung) …

Catalytic, stereoselective N-heterocyclic carbene-catalyzed reactions facilitate efficient
construction of many different heterocyclic compounds, such as the enantioenriched 5 …

N-Heterocyclic carbenes (NHCs) belong to the popular family of organocatalysts used in a
wide range of reactions, including that for the synthesis of complex natural products and …

Fluorinated ketones are widely prevalent in numerous biologically interesting molecules,
and the development of novel transformations to access these structures is an important task …

This review highlights a number of additives that can be used to make asymmetric reactions
perfect. Without changing other reaction conditions, simply adding additives can lead to …

The use of NHCs for generating homoenolate species has gained widespread popularity in
recent years. A number of highly stereoselective processes of NHC-homoenolates have …