Acute lymphoblastic leukaemia develops in both children and adults, with a peak incidence
between 1 year and 4 years. Most acute lymphoblastic leukaemia arises in healthy …

Acute lymphoblastic leukaemia occurs in both children and adults but its incidence peaks
between 2 and 5 years of age. Causation is multifactorial and exogenous or endogenous …

Acute lymphoblastic leukaemia, a malignant disorder of lymphoid progenitor cells, affects
both children and adults, with peak prevalence between the ages of 2 and 5 years. Steady …

Acute kidney injury due to high‐dose methotrexate (HDMTX) is a serious, life‐threatening
toxicity that can occur in pediatric and adult patients. Glucarpidase is a treatment approved …

Folate-mediated one carbon (1C) metabolism supports a series of processes that are
essential for the cell. Through a number of interlinked reactions happening in the cytosol …

As the cure rates for haematological malignancies have improved, the exploration of the
balance between efficacy and side effects has become a major research target. The …

Therapeutic drug monitoring (TDM) is an essential clinical practice for optimizing drug
dosing, thereby preventing adverse effects of drugs with a narrow therapeutic window, slow …

Therapeutic drug monitoring (TDM) can improve clinical care when using drugs with
pharmacokinetic variability and a narrow therapeutic window. Rapid, reliable, and easy-to …

High-dose methotrexate (HDMTX) plays an important role in the treatment of acute
lymphoblastic leukemia (ALL) although there is great inter-patient variability in the efficacy …

During chemotherapy for childhood acute lymphoblastic leukemia, all organs can be
affected by severe acute side effects, the most common being opportunistic infections …