Circulating platelets as mediators of immunity, inflammation, and thrombosis

M Koupenova, L Clancy, HA Corkrey… - Circulation …, 2018 - Am Heart Assoc
Platelets, non-nucleated blood components first described over 130 years ago, are
recognized as the primary cell regulating hemostasis and thrombosis. The vascular …

The era of thromboinflammation: platelets are dynamic sensors and effector cells during infectious diseases

L Guo, MT Rondina - Frontiers in immunology, 2019 - frontiersin.org
Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of
literature supports the evolving role of platelets as key sentinel and effector cells in infectious …

Platelet physiology

T Gremmel, AL Frelinger III… - Seminars in thrombosis …, 2016 - thieme-connect.com
Platelets are the smallest blood cells, numbering 150 to 350× 10 9/L in healthy individuals.
The ability of activated platelets to adhere to an injured vessel wall and form aggregates was …

Platelet-rich plasma: the PAW classification system

JM DeLong, RP Russell, AD Mazzocca - Arthroscopy: the journal of …, 2012 - Elsevier
Platelet-rich plasma (PRP) has been the subject of hundreds of publications in recent years.
Reports of its effects in tissue, both positive and negative, have generated great interest in …

Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery

T Burnouf, ML Chou, DJ Lundy, EY Chuang… - Journal of Biomedical …, 2023 - Springer
Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …

Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming

T Moreau, AL Evans, L Vasquez, MR Tijssen… - Nature …, 2016 - nature.com
The production of megakaryocytes (MKs)—the precursors of blood platelets—from human
pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine …

Platelet function, role in thrombosis, inflammation, and consequences in chronic myeloproliferative disorders

L Repsold, AM Joubert - Cells, 2021 - mdpi.com
Platelets are conventionally defined as playing a vital role in homeostasis and thrombosis.
This role has over the years transformed as knowledge regarding platelets has expanded to …

Antiplatelet therapies for the treatment of cardiovascular disease

AD Michelson - Nature Reviews Drug Discovery, 2010 - nature.com
Antiplatelet therapy has been successful in reducing mortality and morbidity in acute
myocardial infarction. Recent advances in understanding the molecular basis of the role of …

Copy number analysis of the murine platelet proteome spanning the complete abundance range

M Zeiler, M Moser, M Mann - Molecular & Cellular Proteomics, 2014 - ASBMB
Knowledge of the identity and quantity of expressed proteins of a cell type is a prerequisite
for a complete understanding of its molecular functions. Mass-spectrometry-based …

Platelet function analysis

P Harrison - Blood reviews, 2005 - Elsevier
Since the last guidelines for BCSH platelet function testing were written in the late 1980s,
many new tests have become available. Previously most platelet function tests were …