The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic
development, but how they contribute to immune responses in the periphery is unclear …

The interaction of T-cell receptors (TCRs) with self-and non-self-peptides in the major
histocompatibility complex (MHC) stimulates crucial signaling events, which in turn can …

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) with CCR5–donor cells is
the only treatment known to cure HIV-1 in patients with underlying malignancy. This is likely …

The propeller-shaped blades of the PIEZO1 and PIEZO2 ion channels partition into the
plasma membrane and respond to indentation or stretching of the lipid bilayer, thus …

CD28 plays a critical role in regulating immune responses both by enhancing effector T cell
activation and differentiation and controlling the development and function of regulatory T …

Motivation Structural studies of TM domains of single-spanning (bitopic) membrane proteins
are impeded by their instability, flexibility and heterogeneity. The new computational method …

Understanding the generation of an MHC-restricted T cell repertoire is the cornerstone of
modern T cell immunology. The unique ability of αβT cells to only recognize peptide …

CD4+ T cells convert the time that T cell receptors (TCRs) interact with peptides embedded
within class II major histocompatibility complex molecules (pMHCII) into signals that direct …

How T cells become restricted to binding antigenic peptides within class I or class II major
histocompatibility complex molecules (pMHCI or pMHCII, respectively) via clonotypic T-cell …

Abstract CD4+ T cells use T cell receptor (TCR)–CD3 complexes, and CD4, to respond to
peptide antigens within MHCII molecules (pMHCII). We report here that, through~ 435 …