The endocannabinoid system consists of G protein-coupled cannabinoid CB 1 and CB 2
receptors, of endogenous compounds known as endocannabinoids that can target these …

The skin is the primary barrier from the outside environment, protecting the host from injury,
infectious pathogens, water loss and solar ultraviolet radiation. In this role, it is supported by …

A growing number of orphan G-protein-coupled receptors (GPCRs) have been reported to
be activated by lipid ligands, such as lysophosphatidic acid, sphingosine 1-phosphate …

The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA),
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …

A meta‐analysis, unlike a literature review, synthesizes previous studies into new results.
Pooled data from 211 studies measured ligand binding affinities at human (Hs) or rat (Rn) …

Ovarian transplantation is one of the key approaches to restoring fertility in women who
became menopausal as a result of cancer treatments. A major limitation of human ovarian …

Sphingolipids are a fascinating class of signaling molecules derived from the membrane
lipid sphingomyelin. They show abundant expression in the brain. Complex sphingolipids …

Acute lung injury (ALI) attributable to sepsis or mechanical ventilation and subacute lung
injury because of ionizing radiation (RILI) share profound increases in vascular permeability …

Novel immunomodulatory molecule FTY720 is a synthetic analog of myriocin, but unlike
myriocin FTY720 does not inhibit serine palmitoyltransferase. Although many of the effects of …

Sphingolipids such as sphingosine-1-phosphate (S1P), ceramide, or sphingomyelin are
essential constituents of plasma membranes and regulate many (patho) physiological …