Cre/LoxP has broad utility for studying the function, development, and oncogenic
transformation of pancreatic cells in mice. Here we provide an overview of the Cre driver …

This review covers recent advances in understanding the molecular mechanisms controlling
neurogenesis and specification of the developing retina, with a focus on insights obtained …

The poor correlation of mutational landscapes with phenotypes limits our understanding of
the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we …

The ubiquitously expressed non-receptor protein tyrosine phosphatase SHP2, encoded by
PTPN11, is involved in signal transduction downstream of multiple growth factor, cytokine …

KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and
resistant to targeted and immunotherapies. Among the different PDAC subtypes, basal-like …

Physiological levels of Kras G12D are sufficient to induce pancreatic intraepithelial
neoplasias (PanINs); the mechanisms that drive PanIN progression are unknown. Here, we …

Background & Aims One treatment strategy for pancreatic ductal adenocarcinoma is to
modify, rather than deplete, the tumor stroma. Constitutive activation of the signal transducer …

Oncogenic Kras activates a plethora of signaling pathways, but our understanding of critical
Ras effectors is still very limited. We show that cell-autonomous phosphoinositide 3-kinase …

SNAIL is a key transcriptional regulator in embryonic development and cancer. Its effects in
physiology and disease are believed to be linked to its role as a master regulator of …

BACKGROUND & AIMS: Early metastasis is a hallmark of pancreatic ductal
adenocarcinoma and responsible for> 90% of pancreatic cancer death. Because little is …