Background Substantial evidence suggests that cognitive deficits might persist after
remission of a major depressive episode. However, results are inconsistent relative to the …

BACKGROUND: Recurrent-episode Major Depressive Disorder (MDD) is associated with a
number of neuropsychological deficits. To date, less is known about whether these are …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Objectives To describe the cognitive and functional impairment in individuals with the first
episode of major depressive disorder (MDD) as compared to controls and individuals with …

Background: Many studies using diffusion tensor imaging (DTI) have demonstrated impaired
white matter integrity in patients with major depressive disorder (MDD), with significant …

Emotional bias in explicit memory is theorized to play a prominent role in the etiology,
maintenance, and recurrence of depression. Even though this cognitive bias is regarded as …

The central theme of personalized medicine is the premise that an individual's unique
physiologic characteristics play a significant role in both disease vulnerability and in …

One of the most replicated findings has been that hippocampus volume is decreased in
patients with major depressive disorder (MDD). Recent volumetric magnetic resonance …

BACKGROUND: Major depressive disorder (MDD) is characterized by abnormalities in both
brain structure and function within a frontolimbic network. However, little is known about the …

The aim of the present study was to use fMRI to examine the neural correlates of engaging
in rumination among a sample of remitted depressed adolescents, a population at high risk …