Biomaterials for intervertebral disc regeneration: Current status and looming challenges

YC Huang, Y Hu, Z Li, KDK Luk - Journal of tissue engineering …, 2018 - Wiley Online Library
A biomaterial‐based strategy is employed to regenerate the degenerated intervertebral disc,
which is considered a major generator of neck and back pain. Although encouraging …

Structure and mechanical function of the inter‐lamellar matrix of the annulus fibrosus in the disc

J Tavakoli, DM Elliott, JJ Costi - Journal of Orthopaedic …, 2016 - Wiley Online Library
The inter‐lamellar matrix (ILM) has an average thickness of less than 30 µm and lies
between adjacent lamellae in the annulus fibrosus (AF). The microstructure and composition …

Lamellar and fibre bundle mechanics of the annulus fibrosus in bovine intervertebral disc

C Vergari, J Mansfield, JR Meakin, PC Winlove - Acta biomaterialia, 2016 - Elsevier
The intervertebral disc is a multicomposite structure, with an outer fibrous ring, the annulus
fibrosus, retaining a gel-like core, the nucleus pulposus. The disc presents complex …

Elastic fibers in the intervertebral disc: From form to function and toward regeneration

D Cyril, A Giugni, SS Bangar… - International Journal of …, 2022 - mdpi.com
Despite extensive efforts over the past 40 years, there is still a significant gap in knowledge
of the characteristics of elastic fibers in the intervertebral disc (IVD). More studies are …

A chemo-mechanical model for osmo-inelastic effects in the annulus fibrosus

A Derrouiche, F Zaïri, F Zaïri - Biomechanics and modeling in …, 2019 - Springer
The annulus fibrosus exhibits complex osmotic and inelastic effects responsible for unusual
transversal behavior with a Poisson's ratio higher than 0.5 in fibers plane and negative (ie …

New findings confirm the viscoelastic behaviour of the inter-lamellar matrix of the disc annulus fibrosus in radial and circumferential directions of loading

J Tavakoli, JJ Costi - Acta Biomaterialia, 2018 - Elsevier
While few studies have improved our understanding of composition and organization of
elastic fibres in the inter-lamellar matrix (ILM), its clinical relevance is not fully understood …

A microstructure-based model for a full lamellar-interlamellar displacement and shear strain mapping inside human intervertebral disc core

K Kandil, F Zaïri, T Messager, F Zaïri - Computers in Biology and Medicine, 2021 - Elsevier
The determinant role of the annulus fibrosus interlamellar zones in the intervertebral disc
transversal and volumetric responses and hence on their corresponding three-dimensional …

The ultra-structural organization of the elastic network in the intra-and inter-lamellar matrix of the intervertebral disc

J Tavakoli, DM Elliott, JJ Costi - Acta biomaterialia, 2017 - Elsevier
The inter-lamellar matrix (ILM)—located between adjacent lamellae of the annulus fibrosus—
consists of a complex structure of elastic fibers, while elastic fibers of the intra-lamellar …

Interlamellar-induced time-dependent response of intervertebral disc annulus: A microstructure-based chemo-viscoelastic model

K Kandil, F Zaïri, A Derrouiche, T Messager, F Zaïri - Acta biomaterialia, 2019 - Elsevier
The annulus fibrosus of the intervertebral disc exhibits an unusual transversal behavior for
which a constitutive representation that considers as well regional effect, chemical sensitivity …

Sensitivity of intervertebral disc finite element models to internal geometric and non-geometric parameters

Y Du, S Tavana, T Rahman, N Baxan… - … in Bioengineering and …, 2021 - frontiersin.org
Finite element models are useful for investigating internal intervertebral disc (IVD)
behaviours without using disruptive experimental techniques. Simplified geometries are …