RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …

Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

The MYC protooncogene functions as a universal amplifier of transcription through
interaction with numerous factors and complexes that regulate almost every cellular process …

Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large
body of evidence indicates that MYC proteins are transcription factors, studying their function …

Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the
operational networks regulating ferroptosis may unravel vulnerabilities that could be …

Oncoproteins of the MYC family drive the development of numerous human tumours. In
unperturbed cells, MYC proteins bind to nearly all active promoters and control transcription …

R-loops are non-B DNA structures that form during transcription when the nascent RNA
anneals to the template DNA strand forming a RNA: DNA hybrid. Understanding the …

Amplification of MYCN is the driving oncogenic change in a subset of high-risk
neuroblastomas. The MYCN protein and the Aurora-A kinase form a complex during the S …

Deregulation of MYC plays an essential role in T cell acute lymphoblastic leukemia (T-ALL),
yet the mechanisms underlying its deregulation remain elusive. Herein, we identify a …

Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one
of the most important prognostic factors, with children less than 1 year old having favorable …