Metagenomics-enabled microbial surveillance

KKK Ko, KR Chng, N Nagarajan - Nature Microbiology, 2022 - nature.com
Lessons learnt from the COVID-19 pandemic include increased awareness of the potential
for zoonoses and emerging infectious diseases that can adversely affect human health …

Fighting antibiotic resistance in hospital-acquired infections: current state and emerging technologies in disease prevention, diagnostics and therapy

E Avershina, V Shapovalova, G Shipulin - Frontiers in microbiology, 2021 - frontiersin.org
Rising antibiotic resistance is a global threat that is projected to cause more deaths than all
cancers combined by 2050. In this review, we set to summarize the current state of antibiotic …

An omics-based framework for assessing the health risk of antimicrobial resistance genes

AN Zhang, JM Gaston, CL Dai, S Zhao, M Poyet… - Nature …, 2021 - nature.com
Antibiotic resistance genes (ARGs) are widespread among bacteria. However, not all ARGs
pose serious threats to public health, highlighting the importance of identifying those that are …

[HTML][HTML] Assessment of global health risk of antibiotic resistance genes

Z Zhang, Q Zhang, T Wang, N Xu, T Lu, W Hong… - Nature …, 2022 - nature.com
Antibiotic resistance genes (ARGs) have accelerated microbial threats to human health in
the last decade. Many genes can confer resistance, but evaluating the relative health risks of …

[HTML][HTML] A global metagenomic map of urban microbiomes and antimicrobial resistance

D Danko, D Bezdan, EE Afshin, S Ahsanuddin… - Cell, 2021 - cell.com
We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60
cities over 3 years, representing the first systematic, worldwide catalog of the urban …

Deciphering the mobility and bacterial hosts of antibiotic resistance genes under antibiotic selection pressure by metagenomic assembly and binning approaches

R Zhao, K Yu, J Zhang, G Zhang, J Huang, L Ma… - Water research, 2020 - Elsevier
The presence of antibiotics can exert significant selection pressure on the emergence and
spread of antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARB) …

[HTML][HTML] Nanopore sequencing and its application to the study of microbial communities

L Ciuffreda, H Rodríguez-Pérez, C Flores - Computational and structural …, 2021 - Elsevier
Since its introduction, nanopore sequencing has enhanced our ability to study complex
microbial samples through the possibility to sequence long reads in real time using …

Pervasive transmission of a carbapenem resistance plasmid in the gut microbiota of hospitalized patients

R León-Sampedro, J DelaFuente, C Díaz-Agero… - Nature …, 2021 - nature.com
Infections caused by carbapenemase-producing enterobacteria (CPE) are a major concern
in clinical settings worldwide. Two fundamentally different processes shape the …

Short-and long-read metagenomics expand individualized structural variations in gut microbiomes

L Chen, N Zhao, J Cao, X Liu, J Xu, Y Ma, Y Yu… - Nature …, 2022 - nature.com
In-depth profiling of genetic variations in the gut microbiome is highly desired for
understanding its functionality and impacts on host health and disease. Here, by harnessing …

No evidence for a common blood microbiome based on a population study of 9,770 healthy humans

CCS Tan, KKK Ko, H Chen, J Liu, M Loh… - Nature …, 2023 - nature.com
Human blood is conventionally considered sterile but recent studies suggest the presence of
a blood microbiome in healthy individuals. Here we characterized the DNA signatures of …