Alzheimer's disease is the leading cause of dementia worldwide, but the cellular pathways
that underlie its pathological progression across brain regions remain poorly understood …

Alzheimer's disease (AD) has recently been associated with diverse cell states,,,,,,,,,–, yet
when and how these states affect the onset of AD remains unclear. Here we used a data …

Microglia, the macrophages of the brain, are vital for brain homeostasis and have been
implicated in a broad range of brain disorders. Neuroinflammation has gained traction as a …

Sample multiplexing is often used to reduce cost and limit batch effects in single-cell RNA
sequencing (scRNA-seq) experiments. A commonly used multiplexing technique involves …

Aberrant activity of the retrotransposable element long interspersed nuclear element-1 (LINE-
1) has been hypothesized to contribute to cellular dysfunction in age-related disorders …

Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In
familial British dementia (FBD), a mutation in the stop codon of the ITM2B gene (also known …

Microglia play key roles in shaping synaptic connectivity during neural circuits development.
Whether microglia display human-specific features of structural and functional maturation is …

While efforts to identify microglial subtypes have recently accelerated, the relation of
transcriptomically defined states to function has been largely limited to in silico annotations …

All brain areas affected in Parkinson's disease (PD) show an abundance of microglia with an
activated morphology together with increased expression of pro-inflammatory cytokines …

Microglia are a heterogeneous population of tissue macrophages in the central nervous
system (CNS), orchestrating a variety of functions ranging from neurogenesis …