▪ Abstract The intrinsic electrical properties of neurons are shaped in large part by the action
of voltage-gated ion channels. Molecular cloning studies have revealed a large family of ion …

Dendrotoxins are small proteins that were isolated 20 years ago from mamba (Dendroaspis)
snake venoms (Harvey, AL, Karlsson, E., 1980. Dendrotoxin from the venom of the green …

The voltage-gated potassium (Kv) channel subunit Kv1. 1 is a major constituent of
presynaptic A-type channels that modulate synaptic transmission in CNS neurons. Here, we …

Low-threshold voltage-gated potassium currents (I LT) activating close to resting membrane
potentials play an important role in shaping action potential (AP) firing patterns. In the medial …

The computational power of the neocortex arises from interactions of multiple neurons,
which display a wide range of electrical properties. The gene expression profiles underlying …

Neurons are flexible electrophysiological entities in which the distribution and properties of
ionic channels control their behaviors. Through simultaneous somatic and axonal whole-cell …

Molecular determinants of threshold sensitivity of mammalian mechanoreceptors are
unknown. Here, we identify a mechanosensitive (MS) K+ current (I Kmech) that governs …

Potassium channels are crucial regulators of neuronal excitability, setting resting membrane
potentials and firing thresholds, repolarizing action potentials and limiting excitability …

Genes Kcna1 and Kcna2 code for the voltage-dependent potassium channel subunits Kv1.
1 and Kv1. 2, which are coexpressed in large axons and commonly present within the same …

Voltage-dependent K+(Kv) currents in macrophages are mainly mediated by Kv1. 3, but
biophysical properties indicate that the channel composition could be different from that of T …