The cytotoxic anti-cancer drugs cisplatin, paclitaxel, doxorubicin, 5-fluorouracil (5-FU), as
well as targeted drugs including imatinib, erlotinib, and nivolumab, play key roles in clinical …

Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …

Histone deacetylases, as a new class of anticancer targets, could maintain homeostasis by
catalyzing histone deacetylation and play important roles in regulating the expression of …

Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …

The acetylation of histone and non-histone proteins has been implicated in several disease
states. Modulation of such epigenetic modifications has therefore made histone …

The complex mechanism of colorectal cancer development is closely associated with
epigenetic modifications and is caused by overexpression and/or inactivation of oncogenes …

The immune cytokine tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has
attracted rapidly evolving attention as a cancer treatment modality because of its …

Gastrointestinal (GI) cancers, including colorectal, gastric, hepatic, esophageal, and
pancreatic tumors, are responsible for large numbers of deaths around the world …

The human immune defense system routinely expresses the tumour necrosis factor (TNF)-
related apoptosis-inducing ligand (TRAIL), which is the most prevalent element for antitumor …

Non-communicable diseases are increasing and have an underlying low-grade
inflammation in common, which may affect gut health. To maintain intestinal homeostasis …