This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Oxidative stress plays a pivotal role in the development of diabetes complications, both
microvascular and cardiovascular. The metabolic abnormalities of diabetes cause …

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate
hyperglycemia due to lack of or resistance to insulin. Patients with DM are frequently afflicted …

Exosomes, nano-vesicles naturally released from living cells, have been well recognized to
play critical roles in mediating cell-to-cell communication. Given that diabetic hearts exhibit …

Blood vessels constitute the first organ in the embryo and form the largest network in our
body but, sadly, are also often deadly. When dysregulated, the formation of new blood …

The growth of blood vessels (a process known as angiogenesis) is essential for organ
growth and repair. An imbalance in this process contributes to numerous malignant …

BACKGROUND: A chronic wound is tissue with an impaired ability to heal. This is often a
consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency …

The development of tissues and organs is typically driven by the action of a number of
growth factors. However, efforts to regenerate tissues (eg, bone, blood vessels) typically rely …

Animal studies and preliminary results in humans suggest that lower extremity and
myocardial ischemia can be attenuated by treatment with angiogenic cytokines. The resident …