Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …

Histone deacetylases comprise a family of 18 genes, which are grouped into classes I–IV
based on their homology to their respective yeast orthologues. Classes I, II, and IV consist of …

The application of established drug compounds to new therapeutic indications, known as
drug repositioning, offers several advantages over traditional drug development, including …

Purpose: The effects of pan–histone deacetylase (HDAC) inhibitors on cancer cells have
shown that HDACs are involved in fundamental tumor biological processes such as cell …

Hepatocellular carcinoma (HCC) is a significant global health challenge. The activation of
autophagy plays an essential role in promoting the proliferation and survival of cancer cells …

Gene mutations are strongly associated with tumor progression and are well known in
cancer development. However, recently discovered epigenetic alterations have shown the …

Purpose: Medulloblastomas are the most common malignant brain tumors in childhood.
Survivors suffer from high morbidity because of therapy-related side effects. Thus, therapies …

Inhibition of histone deacetylase (HDAC) activity as stand‐alone or combination therapy
represents a promising therapeutic approach in oncology. The pan‐or class I HDAC …

Several microRNA (miRNA) loci are found within genomic regions frequently deleted in
primary neuroblastoma, including miR-885-5p at 3p25. 3. In this study, we demonstrate that …

Medulloblastomas are the most common malignant brain tumors in childhood. Emerging
evidence suggests that medulloblastoma comprises at least four distinct diseases (WNT …