Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a
unique molecular homeostatic 'signature', consisting of a specific transcriptional profile and …

Stress is recognized as an important issue in basic and clinical neuroscience research,
based upon the founding historical studies by Walter Canon and Hans Selye in the past …

As important immune cells, microglia undergo a series of alterations during aging that
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …

Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …

Parkinson's disease (PD) is a common neurodegenerative disease, the pathological
features of which include the presence of Lewy bodies and the neurodegeneration of …

To clarify the role of microglia in brain homeostasis and disease, an understanding of their
maintenance, proliferation and turnover is essential. The lifespan of brain microglia …

Aging results in chronic systemic inflammation that can alter neuroinflammation of the brain.
Specifically, microglia shift to a pro-inflammatory phenotype predisposing them to …

Background Neuronal and glial cell interaction is essential for synaptic homeostasis and
may be affected in Alzheimer's disease (AD). We measured cerebrospinal fluid (CSF) …

Neuroinflammation is a key part of the etio-pathogenesis of Alzheimer's disease (AD). We
tested the relationship between neuroinflammation and the disruption of functional …