Expanding the toolbox of upconversion nanoparticles for in vivo optogenetics and neuromodulation

AH All, X Zeng, DBL Teh, Z Yi, A Prasad… - Advanced …, 2019 - Wiley Online Library
Optogenetics is an optical technique that exploits visible light for selective neuromodulation
with spatio‐temporal precision. Despite enormous effort, the effective stimulation of targeted …

Recent advances in patterned photostimulation for optogenetics

E Ronzitti, C Ventalon, M Canepari, BC Forget… - Journal of …, 2017 - iopscience.iop.org
An important technological revolution is underway in the field of neuroscience as we begin
the 21st century. The combination of optical methods with genetically encoded …

[HTML][HTML] Neural signal propagation atlas of Caenorhabditis elegans

F Randi, AK Sharma, S Dvali, AM Leifer - Nature, 2023 - nature.com
Establishing how neural function emerges from network properties is a fundamental problem
in neuroscience. Here, to better understand the relationship between the structure and the …

Whole-brain calcium imaging with cellular resolution in freely behaving Caenorhabditis elegans

JP Nguyen, FB Shipley, AN Linder… - Proceedings of the …, 2016 - National Acad Sciences
The ability to acquire large-scale recordings of neuronal activity in awake and unrestrained
animals is needed to provide new insights into how populations of neurons generate animal …

Pan-neuronal calcium imaging with cellular resolution in freely swimming zebrafish

DH Kim, J Kim, JC Marques, A Grama… - Nature …, 2017 - nature.com
Calcium imaging with cellular resolution typically requires an animal to be tethered under a
microscope, which substantially restricts the range of behaviors that can be studied. To …

Nanomaterial mediated optogenetics: opportunities and challenges

K Huang, Q Dou, XJ Loh - RSC advances, 2016 - pubs.rsc.org
Optogenetics is a promising neuronal modulation strategy in neuroscience, which enables
real-time neuromodulation in free-moving animals with high spatiotemporal control …

Fast deep neural correspondence for tracking and identifying neurons in C. elegans using semi-synthetic training

X Yu, MS Creamer, F Randi, AK Sharma… - Elife, 2021 - elifesciences.org
We present an automated method to track and identify neurons in C. elegans, called 'fast
Deep Neural Correspondence'or fDNC, based on the transformer network architecture. The …

Quasi‐Continuous Wave Near‐Infrared Excitation of Upconversion Nanoparticles for Optogenetic Manipulation of C. elegans

A Bansal, H Liu, MKG Jayakumar, S Andersson‐Engels… - Small, 2016 - Wiley Online Library
Optogenetics is an emerging powerful tool to investigate workings of the nervous system.
However, the use of low tissue penetrating visible light limits its therapeutic potential …

Brain-wide representations of ongoing behavior: a universal principle?

HS Kaplan, M Zimmer - Current opinion in neurobiology, 2020 - Elsevier
Highlights•A large fraction of the brain's instantaneous activity in worms, flies, and mice
represents the animal's ongoing behavior.•Brain-wide behavioral representations are multi …

Decoding locomotion from population neural activity in moving C. elegans

KM Hallinen, R Dempsey, M Scholz, X Yu, A Linder… - Elife, 2021 - elifesciences.org
We investigated the neural representation of locomotion in the nematode C. elegans by
recording population calcium activity during movement. We report that population activity …