Mechanical damage is one of the predisposing factors of inflammation, and it runs through
the entire inflammatory pathological process. Repeated or persistent damaging mechanical …

Mechanosensitive (MS) ion channels are integral membrane proteins which play a crucial
role in fast signaling during mechanosensory transduction processes in living cells. They are …

The beating heart possesses intrinsic ability to adapt cardiac output to changes in
mechanical load. The century-old Frank-Starling law and Anrep effect have documented that …

Piezo1 is a mechanosensitive cation channel with widespread physiological importance;
however, its role in the heart is poorly understood. Cardiac fibroblasts help preserve …

Mechanosensing is a ubiquitous process to translate external mechanical stimuli into
biological responses. Piezo1 ion channels are directly gated by mechanical forces and play …

Abstract Coronavirus disease 2019 (Covid-19) is a novel worldwide pandemic caused by a
novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). During Covid-19 …

Cardiac fibroblasts (CF) play a pivotal role in preserving myocardial function and integrity of
the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF …

Abstract Purpose of Review: Atherosclerosis is the principal cause of cardiovascular
diseases (CVDs) which are the major cause of death worldwide. Mechanical force plays an …

Ischemic heart disease refers to myocardial degeneration, necrosis, and fibrosis caused by
coronary artery disease. It can lead to severe left ventricular dysfunction (LVEF≤ 35–40%) …

Fibrotic tissues share many common features with neoplasms where there is an increased
stiffness of the extracellular matrix (ECM). In this review, we present recent discoveries …