Chronic Pb Exposure Induces Anxiety and Depression-like Behaviors in Mice via Excitatory Neuronal Hyperexcitability in Ventral Hippocampal Dentate Gyrus

R Zhou, C Huang, N Bi, L Li, C Li, X Gu… - Environmental …, 2023 - ACS Publications
Lead (Pb) is a widespread neurotoxic pollutant. Pb exposure is associated with mood
disorders, with no well-established neural mechanisms elucidated. In the present study, we …

Isochlorogenic acid B alleviates lead-induced anxiety, depression and neuroinflammation in mice by the BDNF pathway

JX Shi, C Cheng, HN Ruan, J Li, CM Liu - Neurotoxicology, 2023 - Elsevier
Lead (Pb) can cause neurobehavioral abnormalities. Isochlorogenic acid B (ICAB), a dietary
flavonoid found in tea, sweet potato, artichoke, propolis and several plants, exhibited …

Sparassis latifolia polysaccharide alleviated lipid metabolism abnormalities in kidney of lead-exposed mice by regulating oxidative stress-mediated inflammation and …

X Lu, S Wu, H Ai, R Wu, Y Cheng, S Yun… - International Journal of …, 2024 - Elsevier
Lead is a common environmental pollutant which can accumulate in the kidney and cause
renal injury. However, regulatory effects and mechanisms of Sparassis latifolia …

Isochlorogenic acid A ameliorated lead-induced anxiety-like behaviors in mice by inhibiting ferroptosis-mediated neuroinflammation via the BDNF/Nrf2/GPX4 …

JT Guo, HY Li, C Cheng, JX Shi, HN Ruan, J Li… - Food and Chemical …, 2024 - Elsevier
Lead (Pb) is a common environmental neurotoxicant that causes behavioral impairments in
both rodents and humans. Isochlorogenic acid A (ICAA), a phenolic acid found in a variety of …

5, 7-dihydroxy-3′, 4′, 5′-trimethoxyflavone mitigates lead induced neurotoxicity in rats via its chelating, antioxidant, anti-inflammatory and monoaminergic …

V Singh, R Shri, P Sood, M Singh, TG Singh… - Food and Chemical …, 2024 - Elsevier
Chronic exposure to lead (Pb) induces neurodegenerative changes in animals and humans.
Drugs with strong antioxidant properties are effective against Pb-mediated neurotoxicity. In a …

Ameliorating effects of Clerodendrum viscosum leaves on lead‐induced hepatotoxicity

E Kabir, J Islam, TT Shila, SA Beauty… - Food Science & …, 2024 - Wiley Online Library
Lead (Pb), a common toxicant is ubiquitously present in the environment. Chronic Pb
exposure affects almost every organ system of human body including liver. Clerodendrum …

Exogenous foods that activate the NRF2 protein: Systematic review

AT Esteves Pairazaman, E Caldas Herrera… - …, 2024 - f1000research.com
Background The activation of the Nuclear factor erythroid 2-related factor 2 (NRF2) signaling
pathway, whether through natural compounds, diet, or supplements, plays a crucial role in …

Concomitant Exposure to Lower Doses of Arsenic, Lead, and Manganese Induces Greater Synergistic Neurotoxicity Than Individual Metals in Mice

E Kabir, TT Shila, J Islam, SA Beauty, F Islam… - … Trace Element Research, 2024 - Springer
People in Bangladesh are often exposed to low to high levels of multiple metals due to
contaminated groundwater with various heavy metals such as arsenic (As), lead (Pb), and …

Folic acid ameliorated the scopolamine-induced memory impairment in mice and the neuroprotective mechanisms

X Xu, J Yang, Z Lu, J Ding, S Lin - Food Bioscience, 2024 - Elsevier
Current research on the neuroprotective regulatory mechanism of folic acid (FA) is limited to
a single DNA methylation pathway. Consequently, this study aimed to explore the …

[HTML][HTML] Fenugreek seed powder protects mice against arsenic-induced neurobehavioral changes

J Islam, Z Islam, N Haque, M Khatun, F Islam… - Current Research in …, 2023 - Elsevier
The current study was designed to evaluate the protective effect of fenugreek seed powder
against As-induced neurobehavioral and biochemical perturbations using a mouse model …