Simple Summary Within this review article the authors provide an unbiased review of the
oncolytic virus, reovirus, clinically formulated as pelareorep. In particular, the authors …

DNA damage response, a key factor involved in maintaining genome integrity and stability,
consists of several kinase-dependent signaling pathways, which sense and transduce DNA …

Background Gemcitabine (GEM) is widely used as an anticancer agent in several types of
solid tumors. Silver nanoparticles (AgNPs) possess unique cytotoxic features and can …

Objective Extensive molecular heterogeneity of pancreatic ductal adenocarcinoma (PDA),
few effective therapies and high mortality make this disease a prime model for advancing …

Gemcitabine is the first-line treatment for locally advanced and metastatic gallbladder cancer
(GBC), but poor gemcitabine response is universal. Here, we utilize a genome-wide …

Pancreatic adenocarcinoma (PDAC) is the fourth leading cause of cancer-related deaths
worldwide; PDAC is characterized by poor prognosis, resistance to conventional …

Pancreatic cancer has become the fourth leading cause of cancer death in the last two
decades. Only 3%-15% of patients diagnosed with pancreatic cancer had 5 year survival …

Pancreatic ductal adenocarcinoma (PDAC) is highly lethal. MUC4 (mucin4) is a heavily
glycosylated protein aberrantly expressed in PDAC and promotes tumorigenesis via an …

We utilized three tiers of screening to identify novel therapeutic agents for pancreatic
cancers. First, we analyzed 14 pancreatic cancer cell lines against a panel of 66 small …

Background Tumors of the gastrointestinal tract impose a substantial healthcare burden due
to their prevalence and challenging prognosis. Methods We conducted a review of peer …