Isothermal titration calorimetry experiments can provide significantly more detailed
information about molecular interactions when combined in global analysis. For example …

Cooperative binding pervades Nature. This review discusses the use of isothermal titration
calorimetry (ITC) in the identification and characterisation of cooperativity in biological …

Multisite interactions and the formation of ternary or higher‐order protein complexes are
ubiquitous features of protein interactions. Cooperativity between different ligands is a …

The binding of penetratin, a peptide that has been found useful for cellular delivery of large
hydrophilic molecules, to negatively charged vesicles was investigated. The surface charge …

Elucidation of the energetic principles of binding affinity and specificity is a central task in
many branches of current sciences: biology, medicine, pharmacology, chemistry, material …

Allostery is a nearly ubiquitous feature of biological systems in which ligand binding or
covalent modification at one site alters the activities of distant sites in a macromolecule or …

The availability of new, high-sensitivity titration calorimeters has made isothermal titration
calorimetry increasingly popular for the study of peptide-membrane interactions. Unlike most …

Isothermal titration calorimetry was used to characterize and quantify the partition of
indomethacin and acemetacin between the bulk aqueous phase and the membrane of egg …

During the past decade, computer simulations of bilayers have moved from the realm of
model systems to realistic systems containing tens of phospholipids along with the requisite …

The phytoalexin resveratrol has received increasing attention for its potential to prevent
oxidative damages in human organism. To shed further light on molecular mechanisms of its …