The process of hemostatic plug formation at sites of vascular injury crucially relies on the
large multimeric plasma glycoprotein von Willebrand factor (VWF) and its ability to recruit …

Von Willebrand disease (VWD) is a bleeding disorder that is mainly caused by mutations in
the multimeric protein von Willebrand factor (VWF). These mutations may lead to …

Von Willebrand factor (VWF) activates in response to shear flow to initiate hemostasis, while
aberrant activation could lead to thrombosis. Above a critical shear force, the A1 domain of …

Von Willebrand factor (VWF), a blood multimeric protein with a very high molecular weight,
plays a crucial role in the primary haemostasis, the physiological process characterized by …

Adhesive molecular bonds between blood cells are essential for thrombosis and hemostasis
as they provide means for platelet adhesion, aggregation, and signaling in flowing blood …

Essentials• The mechanism for the auto‐inhibition of von Willebrand factor (VWF) remains
unclear.• Hydrogen exchange of two VWF A1 fragments with disparate activities was …

Background Genetically determined amino acid substitutions in the platelet adhesive A1
domain alter von Willebrand factor's (VWF) platelet agglutination competence, resulting in …

Decellularization, sterilization, and hemocompatibility are the main areas for biomaterials
evaluation when the material is designed for medical implants. The glutaraldehyde fixation …

Activation of von Willebrand factor (VWF) is a tightly controlled process governed primarily
by local elements around its A1 domain. Recent studies suggest that the O-glycosylated …

Integrins are transmembrane heterodimeric glycoproteins, present in most cell types that act
as mechanoreceptors, connecting extracellular matrix proteins to the cytoskeleton of the cell …