Breaking through the glioblastoma micro-environment via extracellular vesicles

T Simon, E Jackson, G Giamas - Oncogene, 2020 - nature.com
Glioblastoma (GBM) is the most common and most aggressive brain tumour. Prognosis
remains poor, despite the combined treatment of radio-and chemotherapy following surgical …

Emerging biomarkers for non-invasive diagnosis and treatment of cancer: a systematic review

S Zakari, NK Niels, GV Olagunju, PC Nnaji… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Cancer remains a global health challenge, necessitating continuous advancements in
diagnostic and treatment strategies. This review focuses on the utility of non-invasive …

The nomogram model predicting overall survival and guiding clinical decision in patients with glioblastoma based on the SEER database

H Li, Y He, L Huang, H Luo, X Zhu - Frontiers in oncology, 2020 - frontiersin.org
Background: Patients with glioblastoma have a poor prognosis. We want to develop and
validate nomograms for predicting overall survival in patients with glioblastoma. Methods …

Challenges and perspectives of standard therapy and drug development in high-grade gliomas

SS Chelliah, EAL Paul, MNA Kamarudin, I Parhar - Molecules, 2021 - mdpi.com
Despite their low incidence rate globally, high-grade gliomas (HGG) remain a fatal primary
brain tumor. The recommended therapy often is incapable of resecting the tumor entirely …

Development and validation of a deep learning-based survival prediction model for pediatric glioma patients: a retrospective study using the SEER database and …

Y Jiao, J Ye, W Zhao, Z Fan, Y Kou, S Guo… - Computers in Biology …, 2024 - Elsevier
Objective Develop a time-dependent deep learning model to accurately predict the
prognosis of pediatric glioma patients, which can assist clinicians in making precise …

Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics

S Tierling, WM Jürgens-Wemheuer, A Leismann… - Clinical …, 2022 - Springer
Background Promoter methylation of the DNA repair gene O 6-methylguanine-DNA
methyltransferase (MGMT) is an acknowledged predictive epigenetic marker in glioblastoma …

Zinc as a plausible epigenetic modulator of glioblastoma multiforme

N Kumar, S Satarker, M Nampoothiri - European Journal of …, 2020 - Elsevier
Glioblastoma Multiforme (GBM) is an aggressive brain tumor (WHO grade 4 astrocytoma)
with unknown causes and is associated with a reduced life expectancy. The available …

The Significance of MGMT Promoter Methylation Status in Diffuse Glioma

N Jovanović, M Lazarević, VJ Cvetković… - International Journal of …, 2022 - mdpi.com
A single-institution observational study with 43 newly diagnosed diffuse gliomas defined the
isocitrate dehydrogenase 1 and 2 (IDH1/2) gene mutation status and evaluated the …

High Thioredoxin Domain-Containing Protein 11 Expression Is Associated with Tumour Progression in Glioma

YT Chen, CL Chung, YW Cheng, CJ Lin… - International Journal of …, 2023 - mdpi.com
Glioblastoma (GBM) is the most common primary brain malignancy in adults. Despite
multimodal treatment that involves maximal safe resection, concurrent chemoradiotherapy …

Current Combinatorial Therapeutic Aspects: The Future Prospect for Glioblastoma Treatment

M Gautam, R Gabrani - Current Medical Science, 2024 - Springer
There are several types of brain tumors but glioblastoma (GBM) is one of the highly
malignant tumors. A primary concern with GBM is that the treatment is inadequate. Even …